- Title
- Individual patient profiling using clinical and neuroradiological biomarkers in acute ischemic stroke: application of advanced multimodal neuroimaging
- Creator
- Bhaskar, Sonu
- Relation
- University of Newcastle Research Higher Degree Thesis
- Resource Type
- thesis
- Date
- 2017
- Description
- Research Doctorate - Doctor of Philosophy (PhD)
- Description
- The aim of the thesis is to study clinical and neuroradiological biomarkers towards individual patient profiling in acute ischaemic stroke (AIS). There is existing evidence that individual patient profiling using a combination of initial stroke severity, infarct topography and surrogate neuroimaging markers provide clinicians with prognostically relevant information that can guide the selection of patients for acute interventions and/or planning and conduct of rehabilitation. Perilesional brain perfusion neuroimaging and cortical venous drain angiography may be additional measures of prognostic relevance. Combinations of these prognostic variables could potentially allow the development of more sophisticated approaches to selection of post-stroke patients for recovery assistance interventions and AIS patients for thrombolytic and/or endovascular treatments. The overall goal of the thesis is to examine specific subgroups of AIS patients and assess functional outcome, where subgroups are defined by, (a) clinically in terms of stroke severity profile (measured using National Institute of Health Stroke Severity (NIHSS) scale), and (b) neuroradiologically depending upon: lesion topography, presence or absence of peri-lesional hyperperfusion, and presence or absence of delayed late venous phase cortical vein filling (delayed-LCVF). Advanced neuroimaging such as arterial spin labelling (ASL) magnetic resonance imaging (MRI) and dynamic computed tomography angiography (dCTA) can be effectively used to discern surrogate imaging biomarkers, investigate underlying post-ischemic pathophysiological mechanisms, identify stroke subtype, and predict the clinical course of AIS patients receiving reperfusion therapy.
- Subject
- acute ischemic stroke; neurology; prognosis; treatment; neurointervention; ischemia; perfusion imaging; thesis by publication; neuroradiology; biomarkers; Arterial Spin Labelling (ASL); Magnetic Resonance Imaging (MRI); Computed Tomography (CT); CT Angiography (CTA); reperfusion therapy; thrombolysis
- Identifier
- http://hdl.handle.net/1959.13/1342980
- Identifier
- uon:29075
- Rights
- Copyright 2017 Sonu Bhaskar
- Language
- eng
- Hits: 2449
- Visitors: 3671
- Downloads: 724
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT01 | Thesis | 8 MB | Adobe Acrobat PDF | View Details Download | ||
| View Details Download | ATTACHMENT02 | Abstract | 1 MB | Adobe Acrobat PDF | View Details Download |