- Title
- Localisation of tachykinin NK₁ and NK₃ receptors in the human prefrontal and visual cortex
- Creator
- Tooney, Paul A.; Au, Gough G.; Chahl, Loris A.
- Relation
- Neuroscience Letters Vol. 283, Issue 3, p. 185-188
- Publisher Link
- http://dx.doi.org/10.1016/S0304-3940(00)00979-4
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- journal article
- Date
- 2000
- Description
- The distribution of tachykinin NK₁ and NK₃ receptors in the prefrontal (Brodmann area 9) and visual cortex (Brodmann area 17) of formalin-fixed postmortem human brain tissue was studied by immunohistochemistry. NK₁-like immunoreactivity (NK₁-LI) was observed as a thin band at the cortical surface and dots of NK₁-LI localised on small non-pyramidal cells and in the neuropil (layers I–III). NK₃-LI was found in beaded fibres and cells with astrocyte-like morphology in the superficial cortical layers and white matter. Dots of NK₃-LI were prominent in the neuropil and on pyramidal (layers III/V) and non-pyramidal (layers V/VI) cells. The NK₃-LI was more abundant and widespread than the NK₁-LI. This is the first report of the distribution of the NK₁ receptor in the prefrontal and visual cortex of the human brain by immunohistochemistry.
- Subject
- tachykinin; NK₁ receptor; NK₃ receptor; human brain; prefrontal cortex; visual cortex; immunohistochemistry
- Identifier
- uon:2883
- Identifier
- http://hdl.handle.net/1959.13/31994
- Identifier
- ISSN:0304-3940
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