- Title
- Synthesis and antibacterial evaluation of novel hydrophilic ocotillol-type triterpenoid derivatives from 20(S)-protopanaxadiol
- Creator
- Bi, Yi; Ma, Cong; Zhou, Zhiwen; Zhang, Tingting; Zhang, Hengyuan; Zhang, Xiaochen; Lu, Jing; Meng, Qingguo; Lewis, Peter J.; Xu, Jinyi
- Relation
- Records of Natural Products Vol. 9, Issue 3, p. 356-368
- Relation
- http://www.acgpubs.org/RNP/2015/Volume9/Abstracts%209.1/45-RNP-1407-161.htm
- Publisher
- ACG Publications
- Resource Type
- journal article
- Date
- 2015
- Description
- Triterpenoid saponins are involved in plant defense systems to inhibit bacterial invasion. A new series of hydrophilic ocotillol-type triterpenoid derivatives 5-26 have been synthesized with antibacterial activity against Gram-positive bacteria, including a community associated methicillin-resistant Staphylococcus aureus (CA-MRSA; strain USA300). From this series, compounds 6 and 15 were found to be the most active, both with MIC values of 2 µg/mL against B. subtilis 168 and 8 µg/mL against S. aureus USA300, respectively. Furthermore, subsequent assays showed that compounds 6 and 15 displayed strong synergistic effects at sub-MIC levels against both S. aureus USA300 and B. subtilis 168 when combined with two commercial antibiotics, kanamycin and chloramphenicol. Preliminary structure-activity relationship studies were also performed.
- Subject
- ocotillol; triterpenoid; antibacterial activity; synergistic effect
- Identifier
- http://hdl.handle.net/1959.13/1339039
- Identifier
- uon:28155
- Identifier
- ISSN:1307-6167
- Rights
- © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/.
- Language
- eng
- Full Text
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