- Title
- Staphylococcal phenomics: metabolomic and proteomic responses to environmental stressors
- Creator
- Alreshidi, M. M.; Dunstan, R. H.; Onyango, L. A.; Roberts, T. K.
- Relation
- Microbial Pathogens and Strategies for Combating Them: Science, Technology and Education, Volume 1 p. 690-701
- Relation
- Microbiology Book Series 4
- Relation
- http://www.formatex.info/microbiology4/vol1.html
- Publisher
- Formatex Research Center
- Resource Type
- book chapter
- Date
- 2013
- Description
- Staphylococcal species are opportunistic pathogens known to cause an array of acute and chronic infections. The high pathogenicity of these species is thought to be due to their remarkable capacity to rapidly adapt to changes in environmental conditions. Bacterial response mechanisms for survival in changing environments involve metabolomic, genomic, proteomic and structural adjustments within the cell. It has recently become apparent that substantial heterogeneity exists within the bacterial population to maximise chances of survival of the species. This chapter will highlight the role of rapidly changing compositions of metabolites and proteins as potential response mechanisms to facilitate the survival of staphylococcal species following exposures to various environmental stressors. Such advanced understanding of "phenomics" may help in the development of new strategies for antimicrobial chemotherapy.
- Subject
- staphylococci; proteomic; metabolomic; environmental stressors; small colony variants; phenomics
- Identifier
- http://hdl.handle.net/1959.13/1337129
- Identifier
- uon:27774
- Identifier
- ISBN:9788493984397
- Language
- eng
- Full Text
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