- Title
- Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer
- Creator
- Pundavela, Jay; Roselli, Severine; Hondermarck, Hubert; Faulkner, Sam; Attia, John; Scott, Rodney J.; Thorne, Rick F.; Forbes, John F.; Bradshaw, Ralph A.; Walker, Marjorie M.; Jobling, Phillip
- Relation
- Molecular Oncology Vol. 9, Issue 8, p. 1626-1635
- Publisher Link
- http://dx.doi.org/10.1016/j.molonc.2015.05.001
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2015
- Description
- Infiltration of the tumor microenvironment by nerve fibers is an understudied aspect of breast carcinogenesis. In this study, the presence of nerve fibers was investigated in a cohort of 369 primary breast cancers (ductal carcinomas in situ, invasive ductal and lobular carcinomas) by immunohistochemistry for the neuronal marker PGP9.5. Isolated nerve fibers (axons) were detected in 28% of invasive ductal carcinomas as compared to only 12% of invasive lobular carcinomas and 8% of ductal carcinomas in situ (p=0.0003). In invasive breast cancers, the presence of nerve fibers was observed in 15% of lymph node negative tumors and 28% of lymph node positive tumors (p=0.0031), indicating a relationship with the metastatic potential. In addition, there was an association between the presence of nerve fibers and the expression of nerve growth factor (NGF) in cancer cells (p=0.0001). In vitro, breast cancer cells were able to induce neurite outgrowth in PC12 cells, and this neurotrophic activity was partially inhibited by anti-NGF blocking antibodies. In conclusion, infiltration by nerve fibers is a feature of the tumor microenvironment that is associated with aggressiveness and involves NGF production by cancer cells. The potential participation of nerve fibers in breast cancer progression needs to be further considered.
- Subject
- nerve fibers (axons); tumor microenvironment; nerve growth factor; breast cancer
- Identifier
- http://hdl.handle.net/1959.13/1337095
- Identifier
- uon:27771
- Identifier
- ISSN:1574-7891
- Rights
- © 2015. This manuscript version is made available under the CC-BY-NC-ND 3.0 license https://creativecommons.org/licenses/by-nc-nd/3.0/
- Language
- eng
- Full Text
- Reviewed
- Hits: 2990
- Visitors: 3471
- Downloads: 472
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 2 MB | Adobe Acrobat PDF | View Details Download |