- Title
- Omega-3 polyunsaturated fatty acids and chronic obstructive pulmonary disease
- Creator
- Wood, Lisa G.
- Relation
- Current Opinion in Clinical Nutrition and Metabolic Care Vol. 18, Issue 2, p. 128-132
- Publisher Link
- http://dx.doi.org/10.1097/MCO.0000000000000142
- Publisher
- Lippincott Williams & Wilkins
- Resource Type
- journal article
- Date
- 2015
- Description
- Purpose of review: The aim of the present review was to summarize recent research developments relating omega-3 polyunsaturated fatty acids (PUFAs) and chronic obstructive pulmonary disease (COPD). Recent findings: COPD is a chronic inflammatory disease; hence, omega-3 PUFAs may have beneficial effects. At present, however, there are limited data available regarding the potential for omega-3 PUFAs to be used therapeutically in COPD. In 2012–2013, several observational studies have emerged, which demonstrate that circulating omega-3 PUFA levels in COPD are inversely associated with systemic inflammation and positively associated with clinical outcomes. To date, all interventions incorporating omega-3 PUFAs in COPD have used nutrient combinations, such that the specific effects of omega-3 PUFAs cannot be determined. Three clinical trials in COPD are underway, which use therapeutic doses of omega-3 PUFAs alone, with positive results beginning to emerge in 2014. Summary: Observational data support the hypothesis that omega-3 PUFAs may provide a therapeutic strategy for managing COPD. Several intervention trials using omega-3 PUFAs in COPD are underway, which will provide a substantive amount of new data to inform the field and allow evidence-based advice to be generated for patients with COPD in the near future.
- Subject
- chronic obstructive pulmonary disease; exercise capacity; inflammation; lung function; muscle strength; omega-3 fatty acids
- Identifier
- http://hdl.handle.net/1959.13/1334227
- Identifier
- uon:27246
- Identifier
- ISSN:1363-1950
- Language
- eng
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