- Title
- Phytochemical properties and anti-proliferative activity of Olea Europaea L. leaf extracts against pancreatic cancer cells
- Creator
- Goldsmith, Chloe D.; Vuong, Quan V.; Sadeqzadeh, Elham; Stathopoulos, Costas E.; Roach, Paul D.; Scarlett, Christopher J.
- Relation
- Molecules Vol. 20, Issue 7, p. 12992-13004
- Publisher Link
- http://dx.doi.org/10.3390/molecules200712992
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2015
- Description
- Olea europaea L. leaves are an agricultural waste product with a high concentration of phenolic compounds; especially oleuropein. Oleuropein has been shown to exhibit anti-proliferative activity against a number of cancer types. However, they have not been tested against pancreatic cancer, the fifth leading cause of cancer related death in Western countries. Therefore, water, 50% ethanol and 50% methanol extracts of Corregiola and Frantoio variety Olea europaea L. leaves were investigated for their total phenolic compounds, total flavonoids and oleuropein content, antioxidant capacity and anti-proliferative activity against MiaPaCa-2 pancreatic cancer cells. The extracts only had slight differences in their phytochemical properties, and at 100 and 200 μg/mL, all decreased the viability of the pancreatic cancer cells relative to controls. At 50 μg/mL, the water extract from the Corregiola leaves exhibited the highest anti-proliferative activity with the effect possibly due to early eluting HPLC peaks. For this reason, olive leaf extracts warrant further investigation into their potential anti-pancreatic cancer benefits.
- Subject
- olive leaf; oleuropein; pancreatic cancer; phenolic compounds; Olea europaea L; antioxidant activity; phytochemicals; biophenols
- Identifier
- http://hdl.handle.net/1959.13/1332770
- Identifier
- uon:26931
- Identifier
- ISSN:1431-5157
- Rights
- © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
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