Identification of inhibitors of bacterial RNA polymerase

Title: Identification of inhibitors of bacterial RNA polymerase
Creator: Yang, Xiao; Ma, Cong; Lewis, Peter J.
Relation: NHMRC.1008014 & ARC.DP110100190 http://purl.org/au-research/grants/nhmrc/1008014
Relation: Methods Vol. 86, p. 45-50
Publisher Link: http://dx.doi.org/10.1016/j.ymeth.2015.05.005
Publisher: Academic Press
Resource Type: journal article
Date: 2015
Description: Very few clinically available antibiotics target bacterial RNA polymerase (RNAP) suggesting it is an underutilized target. The advent of detailed structural information of RNAP holoenzyme (HE) has allowed the design and in silico screening of novel transcription inhibitors. Here, we describe our approach for the design and testing of small molecule transcription inhibitors that work by preventing the interaction between the essential transcription initiation factor σ and RNAP. With the appropriate structural information this approach can be easily modified to other essential protein-protein interactions.
Subject: RNA polymerase; transcription initiation; small molecule inhibitors; protein–protein interaction
Identifier: http://hdl.handle.net/1959.13/1332246
Identifier: uon:26825
Identifier: ISSN:1046-2023
Language: eng
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