- Title
- Albumin hybrid nanoparticles loaded with tyrosine kinase A inhibitor GNF-5837 for targeted inhibition of breast cancer cell growth and invasion
- Creator
- Shargh, Vahid Heravi; Hondermarck, Hubert; Liang, Mingtao
- Relation
- International Journal of Pharmaceutics Vol. 515, Issue 1-2, p. 527-534
- Publisher Link
- http://dx.doi.org/10.1016/j.ijpharm.2016.10.057
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2016
- Description
- Novel albumin hybrid nanoparticles (Alb-HNPs) loaded with tyrosine kinase A (TrkA) inhibitor GNF-5837 were prepared and evaluated for antineoplastic efficacy in a panel of breast cancer cell lines. The nanomedicines (GNF-Alb-HNPs, hydrodynamic diameter ~150nm) were formed through a unique polyelectrolyte complexation process where albumin and GNF-5837 were encapsulated by a stabilizing layer of oppositely charged chitosan and dextran sulfate polysaccharides. GNF-Alb-HNPs showed an excellent colloidal stability and a sustained drug release over more than 24h. We found that these nanomedicines inhibited TrkA phosphorylation and downstream mitogen-activated protein kinase (MAPK) signaling in breast cancer cells specifically, resulting in anti-proliferative and pro-apoptotic effects. Moreover, the migration and invasion activities of cancer cells were dramatically suppressed and the inhibitory effects were much more prominent with GNF-Alb-HNPS than the drug alone. These results show that the GNF-Alb-HNPs may represent a novel approach for targeted breast cancer therapy.
- Subject
- albumin hybrid nanoparticles; TrkA inhibitor; breast cancer; targeted therapy
- Identifier
- http://hdl.handle.net/1959.13/1327816
- Identifier
- uon:25752
- Identifier
- ISSN:1873-3476
- Language
- eng
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