- Title
- Formulation and evaluation of controlled release ethylcellulose and polyethylene glycol microspheres containing metoprolol tartrate
- Creator
- Malipeddi, Venkata Ramana; Awasthi, Rajendra; Dua, Kamal
- Relation
- Interventional Medicine and Applied Science Vol. 8, Issue 2, p. 60-67
- Publisher Link
- http://dx.doi.org/10.1556/1646.8.2016.2.6
- Publisher
- Akademiai Kiado Rt.
- Resource Type
- journal article
- Date
- 2016
- Description
- Metoprolol tartrate is rapidly absorbed from both gastric and intestinal regions, after oral administration. To retard the release rate of the metoprolol tartrate, microspheres were prepared with varying concentrations of a mixture containing ethylcellulose and polyethylene glycol-6000. The prepared microspheres were evaluated for various physicochemical characteristics and in vitro drug release. The percent yield of microspheres was in the range of 75.2-87.3%. The particle size of microspheres was found to be in the range of 73.2-85.5 µm. Fourier transform-infrared spectral analysis and differential scanning calorimetry concluded the absence of any interaction between the drug and the carriers. The release time profile of metoprolol tartrate from microspheres in 0.1 N hydrochloric acid solution was to the extent of 33.4-60.2%. The complete release of metoprolol tartrate occurred from MPT-3 and MPT-4 in phosphate buffer solution (pH 7.4) within 8 and 7 h, respectively, whereas the incomplete release (72.3%) occurred from MPT-1. Nearly, the complete release (98.5%) of metoprolol occurred from MPT-2 in 10 h. Formulation MPT-2 would be a preferred formulation. The release of metoprolol involves diffusion rate limited (R² = 0.9865) as a mechanism from drug release. The prepared microspheres of metoprolol tartrate eliminate the need for multiple dosing and provide patient compliance.
- Subject
- metoprolol tartrate; microspheres; solvent evaporation; controlled drug delivery; antihypertensive drugs
- Identifier
- http://hdl.handle.net/1959.13/1324796
- Identifier
- uon:25125
- Identifier
- ISSN:2061-1617
- Rights
- This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited.
- Language
- eng
- Full Text
- Reviewed
- Hits: 1314
- Visitors: 1760
- Downloads: 492
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 355 KB | Adobe Acrobat PDF | View Details Download |