- Title
- Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals
- Creator
- Ormerod, Kate L.; Wood, David L. A.; Morrison, Mark; Hansbro, Philip M.; Hugenholtz, Philip; Lachner, Nancy; Gellatly, Shaan L.; Daly, Joshua N.; Parsons, Jeremy D.; Dal'Molin, Cristiana G. O.; Palfreyman, Robin W.; Nielsen, Lars K.; Cooper, Matthew A.
- Relation
- NHMRC.1071822 & NHMRC. 1059239
- Relation
- Microbiome Vol. 4, Issue 1
- Publisher Link
- http://dx.doi.org/10.1186/s40168-016-0181-2
- Publisher
- BioMed Central
- Resource Type
- journal article
- Date
- 2016
- Description
- Background: Our view of host-associated microbiota remains incomplete due to the presence of as yet uncultured constituents. The Bacteroidales family S24-7 is a prominent example of one of these groups. Marker gene surveys indicate that members of this family are highly localized to the gastrointestinal tracts of homeothermic animals and are increasingly being recognized as a numerically predominant member of the gut microbiota; however, little is known about the nature of their interactions with the host. Results: Here, we provide the first whole genome exploration of this family, for which we propose the name "Candidatus Homeothermaceae," using 30 population genomes extracted from fecal samples of four different animal hosts: human, mouse, koala, and guinea pig. We infer the core metabolism of "Ca. Homeothermaceae" to be that of fermentative or nanaerobic bacteria, resembling that of related Bacteroidales families. In addition, we describe three trophic guilds within the family, plant glycan (hemicellulose and pectin), host glycan, and a-glucan, each broadly defined by increased abundance of enzymes involved in the degradation of particular carbohydrates. Conclusions: "Ca. Homeothermaceae" representatives constitute a substantial component of the murine gut microbiota, as well as being present within the human gut, and this study provides important first insights into the nature of their residency. The presence of trophic guilds within the family indicates the potential for niche partitioning and specific roles for each guild in gut health and dysbiosis.
- Subject
- gut microbiome; S24-7; homeothermaceae; population genomes; metagenomics; comparative genomics
- Identifier
- http://hdl.handle.net/1959.13/1324512
- Identifier
- uon:25052
- Identifier
- ISSN:2049-2618
- Rights
- © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Language
- eng
- Full Text
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