- Title
- Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men
- Creator
- Albert, Benjamin B.; Derraik, José G. B.; Brennan, Christine M.; Biggs, Janene B.; Garg, Manohar L.; Cameron-Smith, David; Hofman, Paul L.; Cutfield, Wayne S.
- Relation
- American Journal of Clinical Nutrition Vol. 102, Issue 1, p. 49-57
- Publisher Link
- http://dx.doi.org/10.3945/ajcn.114.103028
- Publisher
- American Society for Nutrition
- Resource Type
- journal article
- Date
- 2015
- Description
- Background: Krill is an increasingly popular source of marine n–3 (ω-3) PUFA that is seen as a premium product. However, to our knowledge, the effect of krill-oil supplementation on insulin sensitivity in humans has not been reported. Objective: We assessed whether supplementation with a blend of krill and salmon (KS) oil [which is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] affects insulin sensitivity in overweight men. Design: The design was a randomized, double-blind, controlled crossover trial. A total of 47 men with a mean ± SD age of 46.5 ± 5.1 y, who were overweight [body mass index (in kg/m2) from 25 to 30] but otherwise healthy, received 5 1-g capsules of KS oil or a control (canola oil) for 8 wk and crossed over to another treatment after an 8-wk washout period. The primary outcome was insulin sensitivity assessed by using the Matsuda method from an oral-glucose-tolerance test. Secondary outcomes included lipid profiles, inflammatory markers, 24-h ambulatory blood pressure, and carotid artery intimamedia thickness. Results: Unexpectedly, insulin sensitivity (per the Matsuda index) was 14% lower with the KS oil than with the control oil (P = 0.049). A mediation analysis showed that, after controlling for the likely positive effects of blood EPA and DHA (i.e., the omega-3 index), the reduction in insulin sensitivity after KS-oil supplementation was more marked [27% lower than with the control oil (P = 0.009)]. Conclusions: Supplementation with a blend of KS oil is associated with decreased insulin sensitivity. Thus, krill-oil supplementation in overweight adults could exacerbate risk of diabetes and cardiovascular disease.
- Subject
- cholesterol; omega-3; insulin sensitivity; lipids; males; n-3 PUFA; nutraceutical
- Identifier
- http://hdl.handle.net/1959.13/1320288
- Identifier
- uon:24117
- Identifier
- ISSN:0002-9165
- Language
- eng
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