- Title
- Surprising sequential effects on MMN
- Creator
- Frost, Jade D.; Winkler, István; Provost, Alexander; Todd, Juanita
- Relation
- NHMRC.1002995
- Relation
- Biological Psychology Vol. 116, Issue April 2016, p. 47-56
- Publisher Link
- http://dx.doi.org/10.1016/j.biopsycho.2015.10.005
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2016
- Description
- The mismatch negativity (MMN) is conceptualized as a confidence-weighted error signal elicited when a deviation violates the predicted next-state based on regularity. The mechanisms underpinning its generation remain contentious. Smaller MMN response is a robust finding in schizophrenia and reduced amplitude may implicate impairment in prediction-error signalling. An enriched understanding of factors that influence MMN size in healthy people is a prerequisite for translating the relevance of reduced MMN in schizophrenia. This paper features two studies designed to explore factors that impact MMN in healthy individuals. Study 1 confirms that MMN amplitude does not faithfully reflect transition statistics and is susceptible to order-driven bias. In study 2, we demonstrate that an order-driven bias remains despite repeated encounters with sound sequences. These data demonstrate that factors that impact on MMN size in non-clinical groups are not fully understood and that some mechanisms driving relevance filtering are likely influenced by 'top-down' expectations.
- Subject
- schizophrenia; context; bias; first-impressions; ERP; auditory; mismatch negativity
- Identifier
- http://hdl.handle.net/1959.13/1320185
- Identifier
- uon:24086
- Identifier
- ISSN:0301-0511
- Language
- eng
- Full Text
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