- Title
- A comparison of the acute toxicities using moderate hypo-fractionated intensity-modulated radiation therapy or volumetric modulated arc therapy for the treatment of early-stage prostate cancer
- Creator
- Elith, Craig A.; Dempsey, Shane E.; Warren-Forward, Helen M.
- Relation
- Journal of Radiotherapy in Practice Vol. 14, Issue 3, p. 274-284
- Publisher Link
- http://dx.doi.org/10.1017/S1460396915000242
- Publisher
- Cambridge University Press
- Resource Type
- journal article
- Date
- 2015
- Description
- Aim: This study compared the acute toxicities reported during radiotherapy treatment using either intensity-modulated radiation therapy (IMRT) or volumetric-modulated arc therapy (VMAT) to deliver a moderate hypo-fractionated treatment for early-stage prostate cancer. Material and methods: Acute toxicities are routinely reported at the clinical site for all patients using the Common Terminology Criteria for Adverse Events. Toxicity assessment is performed on day 1 of treatment, then once weekly thereafter. The recorded toxicities of 40 cases treated with five-field IMRT, and 32 cases treated using VMAT were retrospectively compared. All cases were prescribed 73.68 Gy in 28 fractions. Eight symptoms were assessed; diarrhoea, proctitis, fatigue, pain, dermatitis, urinary frequency, urinary retention and urinary tract pain. Results: In terms of the overall toxicity recorded, VMAT was shown to reduce the toxicities of dermatitis, fatigue, pain and urinary frequency (p<0.05). Using IMRT, grade 2 toxicities were reported for proctitis, pain, urinary frequency, urinary retention and urinary tract pain. Using VMAT, grade 2 toxicities were reported for urinary frequency and urinary retention. Findings: The research reported here is one of the first publications to demonstrate that VMAT is associated with decreased toxicities compared with IMRT for the treatment of early-stage prostate cancer.
- Subject
- IMRT; prostate; RapidArc; toxicity; VMAT
- Identifier
- http://hdl.handle.net/1959.13/1317393
- Identifier
- uon:23408
- Identifier
- ISSN:1460-3969
- Language
- eng
- Full Text
- Reviewed
- Hits: 2274
- Visitors: 2819
- Downloads: 372
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 309 KB | Adobe Acrobat PDF | View Details Download |