- Title
- Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case-control sample of schizophrenia
- Creator
- Ingason, A.; Giegling, I.; Collier, D. A.; O'Donovan, M. C.; Mirnics, K.; Rujescu, D.; Henskens, Frans A.; Cairns, Murray J.; Kelly, Brian J.; Loughland, Carmel M.; Schall, Ulrich; Scott, Rodney J.; Hartmann, A. M.; Tooney, Paul A.; Michie, Patricia T.; Wu, Jing Qin; Genius, J.; Konte, B.; Friedl, M.; Schizophrenia Working Group of the Psychiatric Genomics Consortium (PGC),; Ripke, S.; Sullivan, P. F.; St. Clair, D.
- Relation
- Translational Psychiatry Vol. 5, Issue 10, p. e656-e656
- Publisher Link
- http://dx.doi.org/10.1038/tp.2015.151
- Publisher
- Nature Publishing
- Resource Type
- journal article
- Date
- 2015
- Description
- Antagonists of the N-methyl-D-aspartate (NMDA)-type glutamate receptor induce psychosis in healthy individuals and exacerbate schizophrenia symptoms in patients. In this study we have produced an animal model of NMDA receptor hypofunction by chronically treating rats with low doses of the NMDA receptor antagonist MK-801. Subsequently, we performed an expression study and identified 20 genes showing altered expression in the brain of these rats compared with untreated animals. We then explored whether the human orthologs of these genes are associated with schizophrenia in the largest schizophrenia genome-wide association study published to date, and found evidence for association for 4 out of the 20 genes: SF3B1, FOXP1, DLG2 and VGLL4. Interestingly, three of these genes, FOXP1, SF3B1 and DLG2, have previously been implicated in neurodevelopmental disorders.
- Subject
- NMDA receptor hypofunction; schizophrenia; genome-wide association study; FOXP1; SF3B1; DLG2
- Identifier
- http://hdl.handle.net/1959.13/1316933
- Identifier
- uon:23292
- Identifier
- ISSN:2158-3188
- Language
- eng
- Full Text
- Reviewed
- Hits: 26230
- Visitors: 17992
- Downloads: 595
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 519 KB | Adobe Acrobat PDF | View Details Download |