- Title
- Overlap of dyspepsia and gastroesophageal reflux in the general population: one disease or distinct entities?
- Creator
- Choung, R. S.; Locke III, G. R.; Schleck, C. D.; Zinsmeister, A. R.; Talley, N. J.
- Relation
- Neurogastroenterology and Motility Vol. 24, Issue 3, p. 229-e106
- Publisher Link
- http://dx.doi.org/10.1111/j.1365-2982.2011.01845.x
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2012
- Description
- Background: The overlap of dyspepsia and gastroesophageal reflux (GER) is known to be frequent, but whether the overlap group is a distinct entity or not remains unclear. The aims of the study was to evaluate whether the overlap of dyspepsia and GER (dyspepsia-GER overlap) occurs more than expected due to chance alone, and evaluate the risk factors for dyspepsia-GER overlap. Methods: In 2008 and 2009, a validated Bowel Disease Questionnaire was mailed to a total of 8006 community sample from Olmsted County, MN. Overall, 3831 of the 8006 subjects returned surveys (response rate 48%). Dyspepsia was defined by symptom criteria of Rome III; GER was defined by weekly or more frequent heartburn and/or acid regurgitation. Key Results: Dyspepsia and GER occurred together more commonly than expected by chance. The somatic symptom checklist score was significantly associated with dyspepsia-GER overlap vs GER alone or dyspepsia alone [OR = 1.9 (1.4, 2.5), and 1.6 (1.2, 2.1), respectively]. Insomnia was also significantly associated with dyspepsia-GER overlap vs. GER alone or dyspepsia alone [OR = 1.4 (1.1, 1.7), OR = 1.3 (1.1, 1.6), respectively]. Moreover, proton pump inhibitor use was significantly associated with dyspepsia-GER overlap vs dyspepsia alone [OR = 2.4 (1.5, 3.8)]. Conclusions & Inferences: Dyspepsia-GER overlap is common in the population and is greater than expected by chance.
- Subject
- dyspepsia; gastroesophageal reflux; population-based study
- Identifier
- http://hdl.handle.net/1959.13/1311633
- Identifier
- uon:22241
- Identifier
- ISSN:1350-1925
- Language
- eng
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