- Title
- Toxicity of a novel anti-tumor agent 20(S)-ginsenoside Rg3: a 26-week intramuscular repeated administration study in rats
- Creator
- Liu, J-P.; Lu, D.; Nicholson, Richard C.; Zhao, W-J.; Li, P-Y.; Wang, F.
- Relation
- Food and Chemical Toxicology Vol. 50, Issue 10, p. 3388-3396
- Publisher Link
- http://dx.doi.org/10.1016/j.fct.2012.07.004
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2012
- Description
- The purpose of this study is to investigate the potential subchronic toxicity of 20(S)- Ginsenoside Rg3(Rg3), by a 26-week repeated intramuscular administration in rats. Rg3 was administrated to rats at dose levels of 0, 4.2, 10.0 or 20.0 mg/kg/day. There was no treatment-related mortality and, at the scheduled autopsy, dose-dependent increases in the absolute and relative spleen weights, of both the 10.0 mg/kg and 20.0 mg/kg dose groups were observed. Absolute and relative kidney weights were significantly elevated in the female 10.0 mg/kg dose group and in the male 20.0 mg/kg dose group. Hematological investigations revealed a dose-dependent increase in the total white blood cell (WBC) count and in the percentage of neutrophils, but a decrease in the percentage of lymphocytes, in rats treated with doses of 10.0/20.0 mg/kg. These effects were completely reversible during the recovery period, and no other adverse effects were observed. It was concluded that the 26-week repeated intramuscular dose of Rg3 caused increases in the spleen and kidney weights, WBC counts and in the percentage of neutrophils, but a decrease in the percentage of lymphocytes, with doses of 10.0 or 20.0 mg/kg/day. The no-observed-adverse-effect level for rats was considered to be 4.2 mg/kg/day.
- Subject
- Rg3; intramuscular administration; rats; subchronic toxicity
- Identifier
- http://hdl.handle.net/1959.13/1307402
- Identifier
- uon:21413
- Identifier
- ISSN:0278-6915
- Language
- eng
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