- Title
- Pharmacometrics: so much mathematics and why planes achieve their destinations with almost perfect results...
- Creator
- Isbister, Geoffrey K.; Bies, Robert
- Relation
- NHMRC.ID1061041
- Relation
- British Journal of Clinical Pharmacology Vol. 79, Issue 1, p. 1-3
- Publisher Link
- http://dx.doi.org/10.1111/bcp.12514
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2015
- Description
- Editorial: The mention of population analysis or pharmacokinetic and pharmacodynamic (PKPD) modelling often sends clinicians and clinical pharmacologists running, not wanting to know about mathematics and understanding complexity. Individualized dosing, optimal design of studies and mechanistic models of physiological processes are all ‘too hard’ often leading to another refrain – ‘and how do we apply this to our clinical practice?’ However, we are prepared to use complex technology and equipment in the practice of medicine that requires high level mathematical complexity, but we fear the use of similar methods to investigate, explore and understand drug therapy, drug effects and disease progression. Should we not be using the most modern methods to quantify and understand clinical pharmacology? Mathematics underlies much of how we function, specifically that we expect pilots and airlines to use the most advanced computers, simulations and analytic techniques to make flying safe. We often rely on global position system (GPS) devices to assist us in arriving at our destinations; require that our computer and smartphone operating systems provide fundamental conveniences and coordinate our schedules, phone calls and information and utilize Google™ to search for information on any number of topics. So why do we struggle with them in understanding drug effects?
- Subject
- pharmacometrics; population analysis; mathematics; pharmacodynamic modelling; PKPD
- Identifier
- http://hdl.handle.net/1959.13/1306185
- Identifier
- uon:21163
- Identifier
- ISSN:0306-5251
- Language
- eng
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