Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors

Title: Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors
Creator: Harper, Callista B.; Popoff, Michel R.; McCluskey, Adam; Robinson, Phillip J.; Meunier, Frederic A.
Relation: Trends in Cell Biology Vol. 23, Issue 2, p. 90-101
Publisher Link: http://dx.doi.org/10.1016/j.tcb.2012.10.007
Publisher: Elsevier
Resource Type: journal article
Date: 2013
Description: Many pathogens hijack existing endocytic trafficking pathways to exert toxic effects in cells. Dynamin controls various steps of the intoxication process used by numerous pathogenic bacteria, viruses, and toxins. Targeting dynamin with pharmaceutical compounds may therefore have prophylactic potential. Here we review the growing number of pathogens requiring dynamin-dependent trafficking to intoxicate cells, outline the mode of internalization that leads to their pathogenicity, and highlight the protective effect of pharmacological and genetic approaches targeting dynamin function. We also assess the methodologies used to investigate the role of dynamin in the intoxication process and discuss the validity and potential pitfalls of using dynamin inhibitors (DIs) as therapeutics.
Subject: dynamin; pathogens; neurotoxins; prophylaxis; trafficking; endocytosis
Identifier: http://hdl.handle.net/1959.13/1300476
Identifier: uon:20084
Identifier: ISSN:0962-8924
Language: eng
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