- Title
- Tissue plasminogen activator (tPA) in acute ischaemic stroke: time for collegiate and consensus
- Creator
- Levi, Chris
- Relation
- Medical Journal of Australia Vol. 180, Issue 12, p. 634-636
- Relation
- http://www.mja.com.au/public/issues/180_12_210604/lev10120_fm.html
- Publisher
- Australasian Medical Publishing Company
- Resource Type
- journal article
- Date
- 2004
- Description
- * Systematic reviews of randomised trials of tPA in acute ischaemic stroke indicate a clear benefit of treating selected patients within 3 hours of stroke onset. Moreover, a net benefit remained after adjustment for chance baseline imbalances between subgroups in stroke severity within one of these trials (National Institute of Neurological Disorders and Stroke [NINDS]). * Rates of favourable outcomes and intracranial haemorrhage comparable with those in randomised trials can be achieved in routine clinical practice; however, translation of net benefit from tPA therapy requires organised and coordinated stroke management across the continuum of care. * Prerequisites for well organised and coordinated acute stroke care are: - consensus among care providers on the use of tPA; - stroke-care teams spanning the gaps between pre-hospital care, emergency departments and stroke units; and - collegiate relations and effective communication networks between care providers.
- Subject
- tissue plasminogen activator; tPA; acute ischaemic stroke; collegiate communication; consensus
- Identifier
- uon:1980
- Identifier
- http://hdl.handle.net/1959.13/27758
- Identifier
- ISSN:0025-729X
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