- Title
- Highly efficient synthesis of the tricyclic core of Taxol by cascade metathesis
- Creator
- Letort, Aurelien; Aouzal, Remi; Ma, Cong; Long, De-Liang; Prunet, Joelle
- Relation
- Organic Letters Vol. 16, Issue 12, p. 3300-3303
- Publisher Link
- http://dx.doi.org/10.1021/ol501304j
- Publisher
- American Chemical Society
- Resource Type
- journal article
- Date
- 2014
- Description
- An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning of the dienyne precursor is performed.
- Subject
- enantioselective synthesis; Taxol; ABC tricyclic core; anticancer drugs
- Identifier
- http://hdl.handle.net/1959.13/1296014
- Identifier
- uon:19179
- Identifier
- ISSN:1523-7052
- Language
- eng
- Reviewed
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