- Title
- Genetic background affects susceptibility in nonfatal pneumococcal bronchopneumonia
- Creator
- Preston, J. A.; Beagley, K. W.; Gibson, P. G.; Hansbro, P. M.
- Relation
- European Respiratory Journal Vol. 23, Issue 2, p. 224-231
- Relation
- http://erj.ersjournals.com/cgi/content/abstract/23/2/224
- Publisher
- European Respiratory Society
- Resource Type
- journal article
- Date
- 2004
- Description
- An inflammatory basis for differences was determined with greater levels of phagocytosis and oxidative burst observed in BALB/c mice. C57BL/6 mice cleared the low inoculum with a reduced immune response; however, C57BL/6 mice are more susceptible to larger inocula, which overwhelms the immune system. These different susceptibilities result from a greater inflammatory response in BALB/c compared with C57BL/6 mice.
- Subject
- genetic background; immune response; infection; nonfatal; pneumococcus; streptococcus pneumoniae
- Identifier
- http://hdl.handle.net/1959.13/27664
- Identifier
- uon:1890
- Identifier
- ISSN:0903-1936
- Language
- eng
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