Start and stop signals of oocyte meiotic maturation

Title: Start and stop signals of oocyte meiotic maturation
Creator: Jones, Keith T.; Lane, Simon I. R.; Holt, Janet E.
Relation: Oogenesis: Part IV p. 183-193
Publisher Link: http://dx.doi.org/10.1007/978-0-85729-826-3_13
Publisher: Springer
Resource Type: book chapter
Date: 2013
Description: Oocytes are made in the fetal ovary and are only ever fertilized some considerable time later in the adult. During this time, they have to undergo two meiotic divisions (meiosis I and II), which must be executed faithfully and on time so as to produce a mature egg, with a haploid chromosome content, that is ovulated into the fallopian tube ready to be fertilized. The two meiotic divisions are controlled by both internal and external (hormonal) triggers, principally executed by changes in the activity of the kinase CDK1 in the oocyte. Here, we focus on how the oocyte controls CDK1 activity at three important time points: (1) the arrest at prophase I in the ovary and the hormone-driven release from this arrest, (2) the progression through meiosis I, and finally (3) the rearrest at metaphase II and subsequent completion of meiosis triggered by a sperm calcium signal.
Subject: anaphase-promoting complex; bivalents; CDK1 cyclin B1; fertilization; meiosis; meiotic maturation; metaphase; oocytes; spindle assembly checkpoint
Identifier: http://hdl.handle.net/1959.13/1066639
Identifier: uon:18182
Identifier: ISBN:9780857298263
Language: eng