- Title
- Causal relationship between body mass index and fetuin-A level in the asian population: a bidirectional mendelian randomization study
- Creator
- Thakkinstian, Ammarin; Chailurkit, Laor; Warodomwichit, Daruneewan; Ratanachaiwong, Wipa; Yamwong, Sukit; Chanprasertyothin, Suwannee; Attia, John; Sritara, Piyamitr; Ongphiphadhanakul, Boonsong
- Relation
- Clinical Endocrinology Vol. 81, Issue 2, p. 197-203
- Publisher Link
- http://dx.doi.org/10.1111/cen.12303
- Publisher
- Wiley-Blackwell Publishing Ltd
- Resource Type
- journal article
- Date
- 2014
- Description
- Objective Fetuin-A is associated with body mass index (BMI) as well as components of the metabolic syndrome. However, it is unclear if fetuin-A affects BMI or the other way around. We therefore assessed the causal association between fetuin-A and BMI or vice versa, utilizing a bidirectional Mendelian randomization approach. Design and Methods This was a study of 2558 subjects from the Electricity Generating Authority of Thailand (EGAT) cohort. Two polymorphisms, that is, rs2248690 in the alpha2-Hereman-Schmid glycoprotein (AHSG) gene and rs9939609 in the fat mass and obesity-associated (FTO) gene were genotyped. Bidirectional causal models were constructed using a two-stage least-square instrumental variable (IV) regression. First, rs2248690 locus was used as the instrumental variable for the effect of circulating fetuin-A on BMI, and then, the FTO rs9939609 locus was used as the instrumental variable for the effect of BMI on circulating fetuin-A. Results Among the 2558 subjects, the prevalence of the minor AHSG (T) and FTO (A) alleles was 17·9% and 22·1%, respectively. The AHSG rs2248690 locus was highly related to serum fetuin-A levels (P < 0·001). Likewise, the FTO rs9939609 locus and BMI were highly associated (P < 0·001). Mendelian randomization analyses showed that circulating fetuin-A, instrumented by the AHSG rs2248690 locus, was associated with BMI (coefficient = 2·26; 95% CI: 0·39, 4·12). In contrast, BMI, instrumented by the FTO rs9939609 locus, was not associated with circulating fetuin-A (coefficient = 0·0007; 95% CI: −0·0242, 0·0256). Conclusion Our findings suggest a causal association leading from circulating fetuin-A to BMI. There was no evidence of reverse causality from BMI to fetuin-A.
- Subject
- fetuin-A; BMI; metabolic syndrome; bidirectional Mendelian randomization
- Identifier
- http://hdl.handle.net/1959.13/1064256
- Identifier
- uon:17504
- Identifier
- ISSN:0300-0664
- Language
- eng
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