- Title
- A flow chemistry approach to norcantharidin analogues
- Creator
- Tarleton, Mark; Young, Kelly A.; Unicomb, Eli; McCluskey, Siobahnn N.; Robertson, Mark J.; Gordon, Christopher P.; McCluskey, Adam
- Relation
- Letters in Drug Design and Discovery Vol. 8, Issue 6, p. 568-574
- Publisher Link
- http://dx.doi.org/10.2174/157018011795906730
- Publisher
- Bentham Science Publishers
- Resource Type
- journal article
- Date
- 2011
- Description
- Acid-ester and acid-amide norcantharidin derivatives are prepared using a ‘one-pot’ synthetic procedure utilizing the ThalesNano H-cube™ flow hydrogenator. Traditionally, rapid library generation and reaction scale up of these analogues was limited by the batch wise hydrogenation of 5,6-dehydronorcantharidin. This was resolved with the use of flow chemistry. With no associated scale up issues, a method was devised to produce norcantharidin, along with acid-ester and acid-amide analogues on any scale necessary for biological screening.
- Subject
- cantharidin; norcantharidin; H-cube; kinomics; acetone; acid ester; nucleophilicity; flow hydrogenation; flow chemistry; protein phosphatase inhibition; anti-malarial; anti-parasitic; Diels; Alder; Parr hydrogenation
- Identifier
- http://hdl.handle.net/1959.13/1063991
- Identifier
- uon:17426
- Identifier
- ISSN:1570-1808
- Language
- eng
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