- Title
- Adult cardiac-resident MSC-like stem cells with a proepicardial origin
- Creator
- Chong, James J. H.; Chandrakanthan, Vashe; Biben, Christine; Zoellner, Hans; Colvin, Emily K.; Pimanda, John E.; Biankin, Andrew V.; Zhou, Bin; Pu, William T.; Prall, Owen W. J.; Harvey, Richard P.; Xaymardan, Munira; Asli, Naisana S.; Li, Joan; Ahmed, Ishtiaq; Heffernan, Corey; Menon, Mary K.; Scarlett, Christopher J.; Rashidianfar, Amirsalar
- Relation
- Cell Stem Cell Vol. 9, Issue 6, p. 527-540
- Publisher Link
- http://dx.doi.org/10.1016/j.stem.2011.10.002
- Publisher
- Cell Press
- Resource Type
- journal article
- Date
- 2011
- Description
- Colony-forming units – fibroblast (CFU-Fs), analogous to those giving rise to bone marrow (BM) mesenchymal stem cells (MSCs), are present in many organs, although the relationship between BM and organ-specific CFU-Fs in homeostasis and tissue repair is unknown. Here we describe a population of adult cardiac-resident CFU-Fs (cCFU-Fs) that occupy a perivascular, adventitial niche and show broad trans-germ layer potency in vitro and in vivo. CRE lineage tracing and embryo analysis demonstrated a proepicardial origin for cCFU-Fs. Furthermore, in BM transplantation chimeras, we found no interchange between BM and cCFU-Fs after aging, myocardial infarction, or BM stem cell mobilization. BM and cardiac and aortic CFU-Fs had distinct CRE lineage signatures, indicating that they arise from different progenitor beds during development. These diverse origins for CFU-Fs suggest an underlying basis for differentiation biases seen in different CFU-F populations, and could also influence their capacity for participating in tissue repair.
- Subject
- mesenchymal stem cells; bone marrow; CFU-Fs; tissue repair
- Identifier
- http://hdl.handle.net/1959.13/1063945
- Identifier
- uon:17422
- Identifier
- ISSN:1934-5909
- Language
- eng
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