- Title
- Galectin-3: its role in asthma and potential as an anti-inflammatory target
- Creator
- Gao, Peng; Simpson, Jodie L.; Zhang, Jie; Gibson, Peter G.
- Relation
- Respiratory Research Vol. 14
- Publisher Link
- http://dx.doi.org/10.1186/1465-9921-14-136
- Publisher
- BioMed Central
- Resource Type
- journal article
- Date
- 2013
- Description
- Galectins constitute an evolutionary conserved family that bind to β-galactosides. Increasing evidence shows that galectins are involved in many fundamental biological processes such as cellular communication, inflammation, differentiation and apoptosis. Changes in galectin-3 (Gal-3) expression are commonly seen in cancer and pre-cancerous conditions, and Gal-3 may be involved in the regulation of diverse cancer cell activities that contribute to tumourigenesis, cancer progression and metastasis. In addition, Gal-3 is a pro-inflammatory regulator in rheumatoid arthritis. Gal-3 has been shown to be involved in many aspects in allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype as well as increased expression of inflammatory mediators. In an in vivo model it was shown that bronchoalveolar lavage (BAL) fluid from ovalbumin-challenged mice contained significantly higher levels of Gal-3 compared to control mice. The molecular mechanisms of Gal-3 in human asthma have not been fully elucidated. This review will focus on what is known about the Gal-3 and its role in the pathophysiological mechanisms of asthma to evaluate the potential of Gal-3 as a biomarker and therapeutic target of asthma.
- Subject
- Galectin-3; inflammation; leukocyte; airway hyperresponsiveness; airway remodeling
- Identifier
- http://hdl.handle.net/1959.13/1062171
- Identifier
- uon:17053
- Identifier
- ISSN:1465-993X
- Language
- eng
- Full Text
- Reviewed
- Hits: 2057
- Visitors: 2412
- Downloads: 396
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT01 | Publisher version (open access) | 784 KB | Adobe Acrobat PDF | View Details Download |