- Title
- Manipulating antioxidant intake in asthma: a randomized controlled trial
- Creator
- Wood, Lisa G.; Garg, Manohar L.; Smart, Joanne M.; Scott, Hayley A.; Barker, Daniel; Gibson, Peter G.
- Relation
- NHMRC
- Relation
- American Journal of Clinical Nutrition Vol. 96, Issue 3, p. 534-543
- Publisher Link
- http://dx.doi.org/10.3945/ajcn.111.032623
- Publisher
- American Society for Nutrition
- Resource Type
- journal article
- Date
- 2012
- Description
- Background: Antioxidant-rich diets are associated with reduced asthma prevalence in epidemiologic studies. We previously showed that short-term manipulation of antioxidant defenses leads to changes in asthma outcomes. Objective: The objective was to investigate the effects of a high-antioxidant diet compared with those of a low-antioxidant diet, with or without lycopene supplementation, in asthma. Design: Asthmatic adults (n = 137) were randomly assigned to a high-antioxidant diet (5 servings of vegetables and 2 servings of fruit daily; n = 46) or a low-antioxidant diet (≤2 servings of vegetables and 1 serving of fruit daily; n = 91) for 14 d and then commenced a parallel, randomized, controlled supplementation trial. Subjects who consumed the high-antioxidant diet received placebo. Subjects who consumed the low-antioxidant diet received placebo or tomato extract (45 mg lycopene/d). The intervention continued until week 14 or until an exacerbation occurred. Results: After 14 d, subjects consuming the low-antioxidant diet had a lower percentage predicted forced expiratory volume in 1 s and percentage predicted forced vital capacity than did those consuming the high-antioxidant diet. Subjects in the low-antioxidant diet group had increased plasma C-reactive protein at week 14. At the end of the trial, time to exacerbation was greater in the high-antioxidant than in the low-antioxidant diet group, and the low-antioxidant diet group was 2.26 (95% CI: 1.04, 4.91; P = 0.039) times as likely to exacerbate. Of the subjects in the low-antioxidant diet group, no difference in airway or systemic inflammation or clinical outcomes was observed between the groups that consumed the tomato extract and those who consumed placebo. Conclusions: Modifying the dietary intake of carotenoids alters clinical asthma outcomes. Improvements were evident only after increased fruit and vegetable intake, which suggests that whole-food interventions are most effective. This trial was registered at http://www.actr.org.au as ACTRN012606000286549.
- Subject
- antioxidants; asthma; diet; fruit and vegetable intake
- Identifier
- http://hdl.handle.net/1959.13/1061339
- Identifier
- uon:16937
- Identifier
- ISSN:0002-9165
- Language
- eng
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