- Title
- A role for H₂S in the microcirculation of newborns: the major metabolite of H₂S (Thiosulphate) is increased in preterm infants.
- Creator
- Dyson, Rebecca M.; Palliser, Hannah K.; Latter, Joanna L.; Chwatko, Grazyna; Glowacki, Rafal; Wright, Ian M. R.
- Relation
- NHMRC.569285
- Relation
- PLoS One Vol. 9, Issue 8
- Publisher Link
- http://dx.doi.org/10.1371/journal.pone.0105085
- Publisher
- Public Library of Science
- Resource Type
- journal article
- Date
- 2014
- Description
- Excessive vasodilatation during the perinatal period is associated with cardiorespiratory instability in preterm neonates. Little evidence of the mechanisms controlling microvascular tone during circulatory transition exists. We hypothesised that hydrogen sulphide (H₂S), an important regulator of microvascular reactivity and central cardiac function in adults and animal models, may contribute to the vasodilatation observed in preterm newborns. Term and preterm neonates (24–43 weeks gestational age) were studied. Peripheral microvascular blood flow was assessed by laser Doppler. Thiosulphate, a urinary metabolite of H₂S, was determined by high performance liquid chromatography as a measure of 24 hr total body H₂S turnover for the first 3 days of postnatal life. H₂S turnover was greatest in very preterm infants and decreased with increasing gestational age (p = 0.0001). H₂S turnover was stable across the first 72 hrs of life in older neonates. In very preterm neonates, H₂S turnover increased significantly from day 1 to 3 (p = 0.0001); and males had higher H₂S turnover than females (p = 0.04). A significant relationship between microvascular blood flow and H₂S turnover was observed on day 2 of postnatal life (p = 0.0004). H₂S may play a role in maintaining microvascular tone in the perinatal period. Neonates at the greatest risk of microvascular dysfunction characterised by inappropriate peripheral vasodilatation - very preterm male neonates - are also the neonates with highest levels of total body H₂S turnover suggesting that overproduction of this gasotransmitter may contribute to microvascular dysfunction in preterms. Potentially, H₂S is a target to selectively control microvascular tone in the circulation of newborns.
- Subject
- newborns; microcirculation; hydrogen sulphide (H2S); neonates
- Identifier
- http://hdl.handle.net/1959.13/1059088
- Identifier
- uon:16522
- Identifier
- ISSN:1932-6203
- Language
- eng
- Full Text
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