- Title
- The role of modifier genes in Lynch Syndrome
- Creator
- Scott, Rodney J.; Reeves, Stuart; Talseth-Palmer, Bente
- Relation
- Colorectal Cancer Biology From Genes To Tumor p. 37-58
- Publisher Link
- http://dx.doi.org/10.5772/1163
- Publisher
- InTech
- Resource Type
- book chapter
- Date
- 2012
- Description
- There are a number of inherited predispositions to colorectal cancer (CRC) which can be broadly categorized into two groups; those with associated polyposis, such as familial adenomatous polyposis and the hamartomatous polyposis syndromes; and those that are linked to the non-polyposis syndromes, such as hereditary non polyposis colorectal cancer (HNPCC). The genetic basis of both the polyposis and non-polyposis syndromes are reflected in the CRC population who have no apparent family history of disease. Approximately 80% of all cases of CRC are associated with chromosomal instability [1] and are likely to have mutations in the Adenomatous Polyposis Coli (APC) gene whereas the remaining 20% with microsatellite instability appears to be due primarily to epigenetic inactivation of the DNA mismatch repair (MMR) gene MLH1 [2].
- Subject
- colorectal cancer (CRC); hereditary non polyposis colorectal cancer (HNPCC); familial adenomatous polyposis
- Identifier
- http://hdl.handle.net/1959.13/1053683
- Identifier
- uon:15650
- Identifier
- ISBN:9789535100621
- Language
- eng
- Full Text
- Hits: 4082
- Visitors: 1970
- Downloads: 297
Thumbnail | File | Description | Size | Format | |||
---|---|---|---|---|---|---|---|
View Details Download | ATTACHMENT01 | Publisher version (open access) | 290 KB | Adobe Acrobat PDF | View Details Download |