- Title
- Understanding and targeting centrally mediated visceral pain in inflammatory bowel disease
- Creator
- Farrell, Kristen E.; Callister, Robert J.; Keely, Simon
- Relation
- NHMRC.APP1067146 | NHMRC|APP1021582
- Relation
- Frontiers in Pharmacology Vol. 5, Issue 27
- Publisher Link
- http://dx.doi.org/10.3389/fphar.2014.00027
- Publisher
- Frontiers Research Foundation
- Resource Type
- journal article
- Date
- 2014
- Description
- Chronic abdominal pain is a debilitating symptom of inflammatory bowel disease (IBD): a chronic inflammatory condition of the gastrointestinal tract, which includes Crohn’s disease (CD) and ulcerative colitis (UC), and is characterised by periods of inflammation and remission. During inflammation, pain is often present due to the activation of afferent nerve endings in the gut by inflammatory mediators (Beyak and Vanner, 2005). Importantly, pain associated with IBD often persists after inflammation has resolved, based on clinical and endoscopic examination, and is often “referred” from the gut to cutaneous or other visceral regions (Minderhoud et al., 2004). Based on what we know about pain processing circuits, this suggests the source of chronic and referred pain lies within the central nervous system (CNS). These clinical observations are supported by work in animal models of visceral inflammation that have provided behavioural, anatomical, molecular and physiological evidence to implicate spinal circuits in the development of altered pain responses in IBD (Farrell et al., 2014). In spite of this evidence, little is known about the precise mechanisms of chronic pain development and maintenance in IBD. This lack of understanding severely limits current therapeutic approaches for IBD pain management.
- Subject
- inflammatory bowel diseases; colitis; visceral pain; spinal cord; central sensitization
- Identifier
- http://hdl.handle.net/1959.13/1043614
- Identifier
- uon:14215
- Identifier
- ISSN:1663-9812
- Rights
- © 2014 Farrell, Callister and Keely. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Language
- eng
- Full Text
- Reviewed
- Hits: 1745
- Visitors: 1946
- Downloads: 297
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT01 | Publisher version (open access) | 299 KB | Adobe Acrobat PDF | View Details Download |