- Title
- The relationship between early Alzheimer’s Disease, Apolipoprotein E genotyping & Hippocampal MRI Volumes
- Creator
- Walsh, Bernard Anthony
- Relation
- University of Newcastle Research Higher Degree Thesis
- Resource Type
- thesis
- Date
- 2014
- Description
- Masters Research - Master of Philosophy (MPhil)
- Description
- This thesis attempts to improve the clinical probability of correctly staging the degree of Alzheimer’s Disease (AD) neuropathology in an individual presenting with the syndrome of early Dementia, by exploring the relationship between the known subtypes of the cerebral protein Apolipoprotein E (ApoE) and the extent of AD neuropathology in such persons, using the surrogate of cerebral MRI volume loss within the Medial Temporal Lobe (MTL) regions as the maker of severity of AD neuropathology. In this thesis Early Dementia is defined as “CDR 1.0” using the Clinical Dementia Rating scale (CDR), this being the classification in most common use by Dementia clinicians. The research subjects were drawn from CDR 1.0 persons residing within the community (as opposed to more serve dementia persons typically needing to reside within assisted care programs and who typically have more advanced neurodegeneration). These subjects are the most likely group where improved definition of the degree of neurodegeneration within an early AD individual would be of most clinical use. No demonstrable relationship between the ApoE ε4 allele and increasing MTL volume loss in early AD was found in the research studies of this thesis and hence the presence of one or more e4 alleles cannot be used by the clinician to estimate pathological disease load within an equivalent degree of cognitive impairment in early AD. One peer reviewed medical literature publication and one published abstract resulted from this thesis work.
- Subject
- Hippocampus; Alzheimer’s Disease; Apolipoprotein E
- Identifier
- http://hdl.handle.net/1959.13/1041620
- Identifier
- uon:13936
- Rights
- Copyright 2014 Bernard Anthony Walsh
- Language
- eng
- Full Text
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| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT01 | Abstract | 60 KB | Adobe Acrobat PDF | View Details Download | ||
| View Details Download | ATTACHMENT02 | Thesis | 1 MB | Adobe Acrobat PDF | View Details Download |