- Title
- Mechanisms of maternal immune tolerance during pregnancy
- Creator
- Schjenken, John E.; Tolosa, Jorge M.; Paul, Jonathan W.; Clifton, Vicki L.; Smith, Roger
- Relation
- Recent Advances in Research on the Human Placenta p. 211-242
- Publisher Link
- http://dx.doi.org/10.5772/33541
- Publisher
- InTech
- Resource Type
- book chapter
- Date
- 2012
- Description
- Throughout their evolution, animals have developed mechanisms which protect them against parasites or infections by detecting and destroying foreign biological material within their own bodies. These mechanisms for excluding “non-self” biological materials whilst at the same time maintaining the integrity of the “self” have evolved for hundreds of millions of years into a highly complex body system, the immune system. Any disbalance or alteration of the mechanisms maintaining the dynamic equilibrium between the “self” and “non-self” recognition could translate into a pathological state (or condition) like autoimmune disease at one end of the scale or immunodeficiency at the other.
- Subject
- maternal immune tolerance; pregnancy; embryo development; placental mammals; maternal-fetal relationship
- Identifier
- http://hdl.handle.net/1959.13/1041089
- Identifier
- uon:13858
- Identifier
- ISBN:9789535101949
- Language
- eng
- Full Text
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