- Title
- Maternal consumption of coffee and tea during pregnancy and risk of childhood ALL: results from an Australian case-control study
- Creator
- Milne, Elizabeth; Royle, Jill A.; Armstrong, Bruce K.; Bennett, Lisa C.; De Klerk, Nicholas H.; Bailey, Helen D.; Bower, Carol; Miller, Margaret; Attia, John; Scott, Rodney J.; Kirby, Maria
- Relation
- Cancer Causes & Control Vol. 22, Issue 2, p. 207-218
- Publisher Link
- http://dx.doi.org/10.1007/s10552-010-9688-1
- Publisher
- Springer
- Resource Type
- journal article
- Date
- 2011
- Description
- Objectives: To investigate whether maternal coffee and/or tea consumption during the last 6 months of pregnancy was associated with risk of childhood ALL. Methods: Data on coffee and tea drinking during pregnancy from 337 case mothers and 697 control mothers were analyzed using unconditional multivariable logistic regression. A meta-analysis of our findings with those of previous studies was also conducted. Results: There was little evidence of an overall association between maternal coffee consumption and risk of ALL: OR 0.89 (95% CI 0.61, 1.30), although there was some suggestion that higher levels of intake might increase the risk in children of non-smoking mothers: OR for 2+ cups/day = 1.44 (95% CI 0.85, 2.42); this was supported by our meta-analysis. Risk was also elevated among cases with chromosomal translocations. The overall OR for maternal tea consumption was 0.82 (95% CI 0.56, 1.18), although the OR for T-cell ALL was 0.21 (95% CI 0.08, 0.51). Among ALL cases with translocations, the ORs for tea consumption tended to be elevated: OR = 1.70 (95% CI 0.79–3.68) for 2+ cups/day. Conclusions:The observed increased risk associated with coffee and tea consumption may be confined to ALL with translocations. These associations should be explored further in large international consortia.
- Subject
- child; coffee; diet; Leukemia; tea
- Identifier
- http://hdl.handle.net/1959.13/937036
- Identifier
- uon:12477
- Identifier
- ISSN:0957-5243
- Language
- eng
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