- Title
- Altered amino acid homeostasis and the development of fatigue by breast cancer radiotherapy patients: a pilot study
- Creator
- Dunstan, R. Hugh; Sparkes, Diane L.; MacDonald, Margaret M.; Roberts, Tim K.; Wratten, Christopher; Kumar, Mahesh B.; Baines, Surinder; Denham, J. W.; Gallagher, Sarah A.; Rothkirch, Tony
- Relation
- Clinical Biochemistry Vol. 44, Issue 2-3, p. 208-215
- Publisher Link
- http://dx.doi.org/10.1016/j.clinbiochem.2010.10.002
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2011
- Description
- Objectives: To examine altered amino acid homeostasis as a predisposing factor of fatigue in female radiotherapy breast cancer patients. Design and methods: Participants underwent breast-conserving surgery and adjuvant breast irradiation and were free from significant fatigue pre-radiotherapy. The Functional Assessment of Cancer Therapy fatigue subscale was used to assess fatigue pre- and post-radiotherapy. Blood biochemistry factors and urinary and plasma amino acid levels were measured. Results: One third of 27 patients developed fatigue and were designated as the fatigued cohort. It was possible to differentiate between fatigued subjects pre- and post-radiotherapy based upon their urinary amino acid profiles. Univariate analysis supported altered amino acid homeostasis within the fatigued cohort. Urinary levels of histidine and alanine were increased pre-radiotherapy whilst threonine, methionine, alanine, serine, asparagine and glutamine levels were higher after 5 weeks of radiotherapy for the fatigued cohort. Conclusions: Fatigue was accompanied by altered amino acid homeostasis with increased amino acid excretion suggestive of a catabolic response.
- Subject
- fatigue; amino acids; radiotherapy; breast cancer
- Identifier
- http://hdl.handle.net/1959.13/936625
- Identifier
- uon:12356
- Identifier
- ISSN:0009-9120
- Language
- eng
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