- Title
- Functional dyspepsia impairs quality of life in the adult population
- Creator
- Aro, P.; Talley, N. J.; Agréus, L.; Johansson, S. E.; Bolling-Sternevald, E.; Storskrubb, T.; Ronkainen, J.
- Relation
- Alimentary Pharmacology & Therapeutics Vol. 33, Issue 11, p. 1215-1224
- Publisher Link
- http://dx.doi.org/10.1111/j.1365-2036.2011.04640.x
- Publisher
- Wiley-Blackwell Publishing
- Resource Type
- journal article
- Date
- 2011
- Description
- Background: Data on the impact of functional dyspepsia on health-related quality of life in the general adult population are scarce. Aim: To explore the impact of functional dyspepsia applying the Rome III definition on health-related quality of life in the general population. Method: A random sample of an adult Swedish population (n = 1001, The Kalixanda study) was invited to undergo an oesophagogastroduodenoscopy. An extended abdominal symptom questionnaire and Short Form-36 (SF-36) questionnaire, which includes eight domains measuring physical, mental and social aspects of quality of life, were completed at the clinic visit just before oesophagogastroduodenoscopy. Results: Two hundred and two (20%) individuals reported uninvestigated dyspepsia (UID), 157 (16%) functional dyspepsia (FD), 52 (5%) epigastric pain syndrome (EPS) and 122 (12%) postprandial distress syndrome (PDS). UID, FD and PDS had a clinically meaningful (a ≥ 5 point) and statistically significant impact (P < 0.05) on health-related quality of life in all SF-36 domains except for Role Emotional. EPS had a significant impact on Bodily Pain and Vitality. Overlap of FD with irritable bowel syndrome (IBS) had a significant impact on Bodily Pain (P = 0.002) and General Health (P = 0.02) while FD overlap with gastro-oesophageal reflux symptoms (GERS) had a significant impact on Bodily Pain (P = 0.02) compared with FD without any overlap with IBS or GERS. Conclusion: Functional dyspepsia impacts all main domains describing physical, mental and social aspects of health-related quality of life in the general population. Overlap of functional dyspepsia with irritable bowel syndrome or gastro-oesophageal reflux symptoms impacts the domain related to bodily pain.
- Subject
- irritable bowel syndrome; gastroesophageal reflux symptoms; abdominal symptoms; dyspepsia; Rome III criteria
- Identifier
- http://hdl.handle.net/1959.13/936242
- Identifier
- uon:12250
- Identifier
- ISSN:0269-2813
- Language
- eng
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