Pathogenesis of ABPA

Title: Pathogenesis of ABPA
Creator: Wark, Peter A. B.; Gibson, Peter
Relation: Aspergillosis: From Diagnosis to Prevention p. 695-706
Publisher Link: http://dx.doi.org/10.1007/978-90-481-2408-4_41
Publisher: Springer
Resource Type: book chapter
Date: 2010
Description: Aspergillus fumigatus is a ubiquitous environmental fungus, which through its size, reproductive cycle, ability to germinate at body temperature, secretion of proteases and its highly antigenic nature is an important pathogen in pulmonary disease. We will review the pathogenesis of this organism in terms of its ability to cause allergic bronchopulmonary aspergillosis (ABPA). This involves reviewing new data that examines the importance of the innate immune response to infection, especially how this limits airway colonisation and minimises the airway inflammatory response. We will also review the importance of adaptive immune responses to the organism, especially how a T helper-2 lymphocyte response and chemokine signalling predisposes to the development of ABPA and is associated with recurring disease.
Subject: Aspergillus fumigatus; adaptive immune responses; pulmonary disease; pathogens; allergic bronchopulmonary aspergillosis (ABPA)
Identifier: http://hdl.handle.net/1959.13/932491
Identifier: uon:11369
Identifier: ISBN:9789048124077
Language: eng

		Thumbnail	File	Description	Size	Format