https://nova.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:33433 Wed 31 Oct 2018 15:26:42 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:33428 -1m^-1Pa^-1), solubility (43.12%) opacity (0.44%) and better mechanical properties, demonstrating the importance of selection of the source of starch. The results also indicated that rice starch had compatibility with ι-carrageenan, and the blend of these two polysaccharides can be potentially used for coating fruit and vegetables.]]> Wed 31 Oct 2018 15:13:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:46765 Wed 30 Nov 2022 10:47:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:14100 Wed 28 Mar 2018 14:07:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:12746 Wed 24 Jul 2013 22:24:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:27039 Medicago truncatula to reach the early cotyledon stage. Here, we address the issue by two approaches. The first one establishes a linkage between embryo development and pod morphology in helping indicate the stage of the zygotic embryo. This is particularly based on the number of pod spirals and development of the spines. An alternative way to complement the in vivo studies is via culturing leaf explants to produce somatic embryos. The medium includes an unusual hormone combination - an auxin (1-naphthaleneacetic acid), a cytokinin (6- benzylaminopurine), abscisic acid and gibberellic acid. The different stages can be discerned growing out of the callus without dissection.]]> Wed 11 Apr 2018 15:45:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:14224 Wed 11 Apr 2018 15:34:56 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:13037 Wed 11 Apr 2018 14:54:35 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:11903 (2)_2n η-function identity and the Rogers–Ramanujan identities. We conjecture our result to generalize even further to also include the Andrews–Gordon identities.]]> Wed 11 Apr 2018 14:32:17 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:9192 Wed 11 Apr 2018 14:31:17 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:9452 Wed 11 Apr 2018 14:22:54 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:13715 Wed 11 Apr 2018 13:08:38 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:31099 Wed 11 Apr 2018 13:02:45 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:6833 Wed 11 Apr 2018 12:36:12 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:13200 Wed 11 Apr 2018 11:58:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:14845 Wed 11 Apr 2018 11:44:20 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:11929 Wed 11 Apr 2018 10:47:33 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:27459 Wed 11 Apr 2018 10:32:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:1468 Wed 11 Apr 2018 10:31:47 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:6550 Wed 11 Apr 2018 10:31:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:12331 Wed 11 Apr 2018 10:18:35 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:12972 Wed 11 Apr 2018 10:04:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:11919 Wed 11 Apr 2018 10:02:52 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:13722 Wed 11 Apr 2018 09:55:47 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:20794 Firmicutes phylum of Gram-positive bacteria and have named it ε. Previously ε had been identified as a small protein (ω₁) that copurified with RNA polymerase. We have solved the structure of ε by X-ray crystallography and show that it is not an ω subunit. Rather, ε bears remarkable similarity to the Gp2 family of phage proteins involved in the inhibition of host cell transcription following infection. Deletion of ε shows no phenotype and has no effect on the transcriptional profile of the cell. Determination of the location of ε within the assembly of RNA polymerase core by single-particle analysis suggests that it binds toward the downstream side of the DNA binding cleft. Due to the structural similarity of ε with Gp2 and the fact they bind similar regions of RNA polymerase, we hypothesize that ε may serve a role in protection from phage infection.]]> Wed 11 Apr 2018 09:30:37 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:1467 Wed 11 Apr 2018 09:20:15 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:13011 Wed 11 Apr 2018 09:15:09 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:52514 Wed 07 Feb 2024 14:33:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:43978 Wed 05 Oct 2022 14:29:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:47819 11.0 µmol/L (p = 0.012), cysteine levels were <255 µmol/L (p = 0.033) and serum folate was <22.0 nmol/L (p = 0.003; in males only). In females, dietary intake of total folate <336 µg/day (p=0.001), natural folate <270 µg/day (p = 0.011), and vitamin B2 < 1.12 mg/day (p = 0.028) was associated with an increased AD risk. These results support Hcy, Cys, and SF as useful biomarkers for AD, irrespective of APOE4 genotype and as such should be considered as part of screening and managing risk of AD.]]> Wed 01 Feb 2023 09:58:55 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:52899 Tue 31 Oct 2023 15:46:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:32378 Tue 29 May 2018 13:55:00 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:36521 Tue 26 May 2020 10:11:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:28807 65 y with MCI were randomized to receive a supplement rich in the long-chain ω-3 PUFAs eicosapentaenoic acid (EPA; 1.67 g EPA + 0.16 g docosahexaenoic acid DHA/d; n = 12) or DHA (1.55 g DHA + 0.40 g EPA/d; n = 12), versus ω-6 PUFA linoleic acid (LA; 2.2 g/d; n = 9) for 6 mo. Results: The intervention did not show an increase in telomere length with treatment and there was a trend toward telomere shortening during the intervention period. Linear mixed modeling produced a robust model although statistically underpowered. Telomere shortening was greatest in the LA group (d = 0.21) than in the DHA (d = 0.12) and EPA groups (d = 0.06). Increased erythrocyte DHA levels were associated with reduced telomere shortening (r = −0.67; P = 0.02) in the DHA group. Conclusion: Telomeric shortening may be attenuated by ω-3 PUFA supplementation, requiring further investigation in larger samples.]]> Tue 16 Jan 2024 16:02:14 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:32238 VI) with fresh, (anoxic) aged and corroded nZVI particles was investigated under aqueous conditions conducive to the formation of thermodynamically stable U(_VI)-Ca-CO₃ ternary aqueous complexes. The first stage of the reaction between U(_VI) and nZVI was assigned to sorption processes with the formation of surface U(_VI)-carbonate complexes. Aged nZVI removed U(_VI) faster than either fresh or corroded nZVI and it is hypothesized that U reduction initially occurs through the transfer of one electron from Fe(_II) in the nZVI surface oxide layer. Evidence for reduction to U(_V) was obtained through X-ray photoelectron spectroscopy and by determination of U-O bond distances of ~2.05 and 2.27 Å, using U L_III -edge X-ray absorption spectroscopy, which are similar to those observed for the U(_v) site in the mixed U(_v)/U(_VI) carbonate mineral wyartite. Scanning transmission electron microscopy also demonstrated that U was present as a nanoparticulate phase after one day of reaction, rather than a surface complex. Further reduction to U(_IV), as observed in previous studies, would appear to be rate-limiting and coincident with the transformation of this meta-stable U-carbonate phase to uraninite (UO).]]> Tue 15 May 2018 16:00:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:45869 Tue 06 Dec 2022 10:22:06 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:43898 Tue 04 Oct 2022 13:59:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:33421 Cucurbita pepo var. cylindrica) were stored at low pressure (4 kPa) at 10°C at 100% relative humidity (RH) for 11 days. Fruit quality was examined upon removal and after being transferred to normal atmosphere (101 kPa) at 20°C for three days. Zucchinis stored at low pressure exhibited a 50% reduction in stem-end browning compared with fruit stored at atmospheric pressure (101 kPa) at 10°C. The benefit of low pressure treatment was maintained after the additional three days storage at normal atmospheric pressure at 20°C. Indeed, low pressure treated fruit transferred to regular atmosphere 20°C for three days possessed a significantly lower incidence of postharvest rot compared to fruit stored at regular atmospheric pressure at 10°C. Zucchinis stored at low pressure showed higher levels of acceptability (28% and 36 % respectively) compared to fruit stored at regular atmospheres at 10°C for both assessment times.]]> Tue 03 Sep 2019 18:18:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:33467 w) than those produced by spray-drying. Specifically, the MC and a_w of the microparticles produced by freeze-drying ranged from 1.15 to 2.15% and 0.13 to 0.14, respectively, while the MC and a_w of the microparticles produced by spray-drying ranged from 6.06% to 6.60% and 0.33 to 0.40, respectively. Scanning electron microscopy revealed that spray-drying resulted in the formation of spherical particles of different sizes regardless of the type of coating agent. Although freeze-drying resulted in microparticles with amorphous glassy shapes, the mixture of MD + soybean protein resulted in the formation of spherical porous particles. X-ray diffraction revealed a low degree of crystallinity for the samples produced by both techniques.]]> Tue 03 Sep 2019 17:59:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:34952 ⊙), cold (14 K) 3.6–70 μm dark IRDC, G331.372-00.116. This infrared dark cloud (IRDC) has the potential to form high-mass stars, and given the absence of current star formation signatures, it seems to represent the earliest stages of high-mass star formation. We have mapped the whole IRDC with the Atacama Large Millimeter/submillimeter Array (ALMA) at 1.1 and 1.3 mm in dust continuum and line emission. The dust continuum reveals 22 cores distributed across the IRDC. In this work, we analyze the physical properties of the most massive core, ALMA1, which has no molecular outflows detected in the CO (2–1), SiO (5–4), and H₂CO (3–2) lines. This core is relatively massive (M = 17.6 M _⊙), subvirialized (virial parameter α _vir = M_vir/M = 0.14), and is barely affected by turbulence (transonic Mach number of 1.2). Using the HCO⁺ (3–2) line, we find the first detection of infall signatures in a relatively massive, prestellar core (ALMA1) with the potential to form a high-mass star. We estimate an infall speed of 1.54 km s⁻¹ and a high accretion rate of 1.96 × 10⁻³ M _⊙ yr⁻¹. ALMA1 is rapidly collapsing, out of virial equilibrium, which is more consistent with competitive accretion scenarios rather than the turbulent core accretion model. On the other hand, ALMA1 has a mass ~6 times larger than the clumps Jeans mass, as it is in an intermediate mass regime (M_J = 2.7 ⊙), contrary to what both the competitive accretion and turbulent core accretion theories predict.]]> Tue 03 Sep 2019 17:56:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:32053 Tue 03 Sep 2019 17:54:08 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:52118 45 K). The detection rate of the N2D+ emission toward the protostellar cores is 38%, which is higher than 9% for the prestellar cores, indicating that N2D+ does not exclusively trace prestellar cores. The detection rates of the DCO+ emission are 35% for the prestellar cores and 49% for the protostellar cores, which are higher than those for N2D+, implying that DCO+ appears more frequently than N2D+ in both prestellar and protostellar cores. Both the N2D+ and DCO+ abundances appear to decrease from the prestellar to the protostellar stage. The DCN, C2D, and 13CS emission lines are rarely seen in the dense cores of early evolutionary phases. The detection rate of the H2CO emission toward dense cores is 52%, three times higher than that for CH3OH (17%). In addition, the H2CO detection rate, abundance, line intensities, and line widths increase with the core evolutionary status, suggesting that the H2CO line emission is sensitive to protostellar activity.]]> Thu 28 Sep 2023 15:04:02 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:52631 4). After lipid extraction, significant increases in δ15N values (0.5‰–1.4‰) were found in shark muscle and liver tissues. For pinniped skin samples, δ15N values were not significantly lower after lipid extraction (−0.4‰ to –0.1‰). Conclusions: Lipid extraction did not have a strong impact on δ34S values of shark muscle and pinniped skin (≤1‰). However, our results suggest it is essential to consider the effects of lipid extraction when interpreting results from δ34S values of shark liver tissue, as they significantly depleted values relative to bulk tissue (~5‰). This may reflect selective removal of sulfolipids and glutathione present in higher concentrations in the liver than in muscle and skin and requires further investigation.]]> Thu 19 Oct 2023 15:12:53 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:15996 Thu 18 Feb 2021 11:21:19 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:32529 de novo missense variant within the C-terminal Sin3-like domain of ZSWIM6 was previously reported to cause acromelic frontonasal dysostosis (AFND), an autosomal-dominant severe frontonasal and limb malformation syndrome, associated with neurocognitive and motor delay, via a proposed gain-of-function effect. We present detailed phenotypic information on seven unrelated individuals with a recurrent de novo nonsense variant (c.2737C > T [p.Arg913Ter]) in the penultimate exon of ZSWIM6 who have severe-profound intellectual disability and additional central and peripheral nervous system symptoms but an absence of frontonasal or limb malformations. We show that the c.2737C > T variant does not trigger nonsense-mediated decay of the ZSWIM6 mRNA in affected individual-derived cells. This finding supports the existence of a truncated ZSWIM6 protein lacking the Sin3-like domain, which could have a dominant-negative effect. This study builds support for a key role for ZSWIM6 in neuronal development and function, in addition to its putative roles in limb and craniofacial development, and provides a striking example of different variants in the same gene leading to distinct phenotypes.]]> Thu 16 Aug 2018 10:03:57 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:11920 Sat 24 Mar 2018 11:09:01 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:832 Sat 24 Mar 2018 10:43:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:30881 machine and the network are two opposing organizational structures, which have been used in different cases for performance, meaning in terms of spatiality. These statements represent two constructions with opposing proprietary features. The machine is described as a series, with a predefined function and a coincidence between the results for a given result, is evaluated with a basic criterion for optimizing the performance. From enlightenment onwards, the has always been a decisive factor in constructing and organizing society. In particular, it constitutes a predominant structural reference to the architecture and urban planning of modernity in order to clearly define the units of a spatial whole and the relations between them. On the other hand, the networks are combined non-linearly, in such a way that the synapses created and the desired results are characterized as flexible, variable, or temporary. In the scientific context of theories developed over the last few decades explaining the relationships between historical, social and cultural events, also data and phenomena of heterogeneous origin, the structure of the network has often been used to determine these elements in relation to their interactions and influences. In this study, we investigate the potential of the net and the network, on the basis of their differences to be set up as complementary structures, with the structure of a composite template. The features of the device and the network are locally detected as the technical achievements of different rulers in terms of their interpretation the rendering of the concept of childhood. Similarly, the possibilities of building a structural machine/network with application to space design are examined. Especially through examples of modernism, from the interwar period and the later years, it can be seen that in the spatial adaptation of the formerly former network, parallel properties best described by the other are satisfied. As a consequence, the standard model/modeling is perceived as appropriate in order to describe, with emphasis on contemporary horizons and orientations, the orientations under which the design, architectural, urban and political, is advanced.]]> Sat 24 Mar 2018 10:17:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:31244 Zymomonas mobilis ZM4 gnlΔ, were investigated via growth inhibitory assay and biotransformation of glucose and fructose into gluconolactone and sorbitol, respectively. The results of ethanol fermentation studies performed in the presence of high concentration of glucose (>200 g l⁻¹) under fermentative or aerobic conditions indicated that a significant reduction of volumetric ethanol productivity from the strain of ZM4 gnlΔ was noticeable due to the reduced rates of specific growth, sugar uptake, and biomass yield as compared with those of the parental strain ZM4. The biotransformation prepared at pH 6.0 using the permeabilized cell indicated that gluconic acid from ZM4 gnlΔ was still produced as a major product (67 g l⁻¹) together with sorbitol (65 g l⁻¹) rather than gluconolactone after 24 h. Only small amount of gluconolactone was transiently overproduced up to 9 g l⁻¹, but at the end of biotransformation, all gluconolactone were oxidized into gluconic acid. This indicated that autolysis of gluconolactone at the pH led to such results despite under gluconolactonase inactivation conditions. The physiological characteristics of ZM4 gnlΔ was further investigated under various stress conditions, including suboptimal pH (3.5~6.0), temperature (25~40 °C), and presence of growth inhibitory molecules including hydrogen peroxide, ethanol, acetic acid, furfural, and so forth. The results indicated that ZM4 gnlΔ was more susceptible at high glucose concentration, low pH of 3.5, and high temperature of 40 °C and in the presence of 4 mM H₂O₂ comparing with ZM4. Therefore, the results were evident that gluconolactonase in Z. mobilis contributed to industrial robustness and anti-stress regulation.]]> Sat 24 Mar 2018 08:44:01 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:31527 Sat 24 Mar 2018 08:43:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:8131 .05, t-test). Diffuse cortical atrophy was detected for both ε4+ (p = .0001, permutation test) and ε4− patients (p = .0001, permutation test) relative to controls, and overall gray matter loss was about 15% in each patients group. Differences in gray matter loss between carriers and non-carriers mapped to the temporal cortex and right occipital pole (20% greater loss in carriers) and to the posterior cingulate, left orbitofrontal and dorsal fronto-parietal cortex (5–15% greater loss in non-carriers). APOE effect in AD was not significant (p > .74, ANOVA), but a significant APOE by region (temporal vs fronto-parietal cortex) interaction was detected (p = .002, ANOVA), in both early and late-onset patients (p < .05, ANOVA). We conclude that the ε4 allele modulates disease phenotype in AD, being associated with a pattern of differential temporal and fronto-parietal vulnerability.]]> Sat 24 Mar 2018 08:40:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:8126 Sat 24 Mar 2018 08:40:02 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:7206 Sat 24 Mar 2018 08:39:55 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:9683 Sat 24 Mar 2018 08:39:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:7578 Sat 24 Mar 2018 08:37:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:9366 Sat 24 Mar 2018 08:36:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:7192 Sat 24 Mar 2018 08:35:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:1701 0 °C at a time when MIS 6 ice volumes were close to their maximum. High stable carbon isotope (δ¹³C) values (−2.8‰ to +3.1‰) throughout the stalagmite's growth reflect a persistently low input of biogenic CO², indicating that the steep, barren and alpine-like recharge area of today has been in existence for at least the last ∼380 kyr. During MIS 9, the lowest δ¹³C values occur well after maximum interglacial conditions, suggesting a lag in the development of post-glacial soils in this high-altitude karst. The stable oxygen isotope (δ¹⁸O) trends match the main structural features of the major climate proxy records (SPECMAP, Vostok and Devils Hole), suggesting that the δ¹⁸O of CC1 has responded to global-scale climate changes, whilst remarkable similarity exists between CC1 δ¹⁸O and regional sea-surface temperature reconstructions from North Atlantic core ODP980 and southwest Pacific marine core MD97-2120 through the most detailed part of the CC1 record, MIS 9–8. The results suggest that CC1 and other stalagmites from the cave have the potential to capture a long record of regional temperature trends, particularly in regards to the relative severity of Pleistocene glacial stages.]]> Sat 24 Mar 2018 08:27:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:15720 Sat 24 Mar 2018 08:25:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:14101 Sat 24 Mar 2018 08:24:01 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:14045 Sat 24 Mar 2018 08:22:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:15765 Sat 24 Mar 2018 08:22:04 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:14588 Sat 24 Mar 2018 08:20:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:13151 1(µ) has a weak Hadamard differentiable renorm (i.e. differentiable away from the origin uniformly on all weakly compact sets) if and only if µ is sigma finite. As a consequence several powerful recent differentiability theorems apply to subspaces of L₁.]]> Sat 24 Mar 2018 08:18:08 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:13145 Sat 24 Mar 2018 08:18:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:13144 Sat 24 Mar 2018 08:18:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:13148 2/3 ₁,) analogous to the classical θ₂(q),θ₃(q),θ₄(q) and the hypergeometric function ₂F₁(1/2,^1/2 ₁,)• We give elliptic function generalizations of a(q), b(q), c(q) analogous to the classical theta-function θ(z,q). A number of identities are proved. The proofs are self-contained, relying on nothing more than the Jacobi triple product identity.]]> Sat 24 Mar 2018 08:18:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:12783 Sat 24 Mar 2018 08:17:34 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:13160 Sat 24 Mar 2018 08:16:05 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:13064 11 and cannot occur if we assume the Generalized Riemann Hypothesis.]]> Sat 24 Mar 2018 08:15:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:13102 Sat 24 Mar 2018 08:15:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:10855 Sat 24 Mar 2018 08:12:42 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:9792 Sat 24 Mar 2018 08:11:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:10483 Sat 24 Mar 2018 08:09:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:18838 Sat 24 Mar 2018 08:03:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:17110 Sat 24 Mar 2018 08:02:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:19583 Sat 24 Mar 2018 07:58:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:17783 Sat 24 Mar 2018 07:57:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:21305 p < 0.05. There were no significant differences between any of the measures over time for all of the variables assessed (F = 0.302-1.576, p = 0.226-0.759, partial η² = 0.029-0.136). For all measurements, intra-rater reliability was high (intra-class correlation > 0.9). These results support the use of formic acid demineralization to facilitate the study of cervical spine meniscoids by dissection, as even after a period of extended immersion in the solution, the morphometry of the structures was not significantly altered. Findings may have implications for dissection studies of other meniscoid-like soft tissue structures that use formic acid demineralization.]]> Sat 24 Mar 2018 07:54:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:6476 Sat 24 Mar 2018 07:47:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:5537 T polymorphism located within the promoter region of the ΔDNMT3B gene has recently been reported to be associated with a significant increase to the risk of early onset CRC. In this study we determined the ΔDNMT3B genotype in 404 confirmed HNPCC participants (total of 194 CRC cases) from Australia (203) and Poland (201). Front the total number of participants there were 194 diagnosed cases of CRC and 210 healthy MMR gene Mutation carriers. The study was undertaken to assess whether the reported effect observed in a previous study of 146 HNPCC patients is consistent in a larger separate and unrelated participant cohort. Through the statistical tests of Kaplan-Meier survival analysis and Cox hazard regression models we did not observe any significant association between the ΔDNMT3B C>T SNP and early onset CRC in HNPCC patients.]]> Sat 24 Mar 2018 07:46:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:6148 Sat 24 Mar 2018 07:44:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:5017 Sat 24 Mar 2018 07:44:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:91 Sat 24 Mar 2018 07:42:14 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:27111 Sat 24 Mar 2018 07:41:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:27862 Sat 24 Mar 2018 07:41:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:30779 2+ and Cu²⁺ on the oxidative degradation of Amoxicillin (AMX) by heterogeneous Fenton-like oxidation using nanoscale zero-valent iron (nZVI) as a catalyst was investigated. It was found that about 90.0% and 54.7% of AMX was degraded in the presence of 1 mM Cu²⁺ and 1 mM Mg²⁺ ions respectively, while 60.2% of AMX was removed by the control sample. Scanning electron microscopy (SEM) indicated that nZVI aggregated visibly after degradation of amoxicillin. X-ray photoelectron spectrometer (XPS) confirmed the reduction of Cu²⁺ to Cu⁰ by Fe⁰ on nZVI’s surface to form similar Fe/Cu bimetal to accelerate the degradation of AMX, and magnesium oxides or hydroxides formed on the surface of nZVI to restrain the removal of AMX. X-ray diffraction (XRD) demonstrated the existence of Fe⁰ in fresh nZVI and the corrosion aggregation of nZVI to form iron oxides or hydroxides after reaction. Kinetics studies demonstrated a pseudo first-order kinetics model for the oxidative degradation with the observed maximum K_obs as 0.0867 min⁻¹ in the presence of 1 mM Cu²⁺. The reason for this enhanced bimetallic catalytic activity is discussed.]]> Sat 24 Mar 2018 07:37:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:22111 Ifn-ε–deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum. Thus, IFN-ε is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden.]]> Sat 24 Mar 2018 07:13:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:24053 -1 was removed using nZVI, while more than 90% of MC-LR was removed using either bimetallic Fe/Ni or Fe/Pd after degrading for 120min. In addition, the results indicated that Fe⁰ was oxided to iron oxide or hydroxide after reacting with MC-LR, while Ni or Pd acted as the catalysis to prevent Fe⁰ corrosion and generating hydrogen via water reduction. Degradation of MC-LR by iron-based nanoparticles fitted well to the pseudo-first order kinetic model and the degradation was a diffusion-controlled reaction with low activation energies (8-21kJmol^-1). Finally, the degradation mechanisms of MC-LR using iron-based nanoparticles were proposed according to the LC-MS analysis. In nZVI case, when the MC-LR was quickly adsorbed on nanoparticles, electron transfer and H₂ generated from iron corrosion were generated and broke down the Adda composition of MC-LR. Based on corrosion in the Fe⁰-H₂O system, bimetallic Fe/Ni and Fe/Pd further utilized the abundant hydrogen radical decomposed from H₂ under the catalysis of Ni or Pd, and destroyed the Adda to form small molecules.]]> Sat 24 Mar 2018 07:09:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:52766 Mon 29 Jan 2024 18:40:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:40395 TP53 SNPs in exon 4 and intron 4 on cancer risk, clinicopathological features and expression of TP53 isoforms. The intron 4 SNPs were significantly over-represented in cohorts of mixed cancers compared to three ethnically matched controls, suggesting they confer increased cancer risk. Further analysis showed that heterozygosity at rs1042522(GC) and either of the two intronic SNPs rs9895829(TC) and rs2909430(AG) confer a 2.34-5.35-fold greater risk of developing cancer. These SNP combinations were found to be associated with shorter patient survival for glioblastoma and prostate cancer. Additionally, these SNPs were associated with tumor-promoting inflammation as evidenced by high levels of infiltrating immune cells and expression of the Δ133TP53 and TP53ß transcripts. We propose that these SNP combinations allow increased expression of the Δ133p53 isoforms to promote the recruitment of immune cells that create an immunosuppressive environment leading to cancer progression.]]> Mon 25 Jul 2022 09:15:39 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:47494 Mon 23 Jan 2023 11:47:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:35470 3−δ perovskites are attractive candidates for high-temperature mixed ionic electronic conduction processes, due to their ability to produce mixed oxidation states and accommodate oxygen vacancies. Here, we examine the electronic structure and high-temperature thermochemistry of stoichiometric and non-stoichiometric cubic BaZrO_3−δ perovskites for high defect concentration (δ = 0-0.5) using first-principles density functional theory (DFT) and density functional perturbation theory (DFPT) calculations. Our results show that the electronic structures of these perovskites under increasing oxygen deficiency are characterized by highly localized reduction of Zr⁴⁺ t_2g orbitals in the vicinity of the oxygen defects, irrespective of the value of δ. Temperature dependent thermodynamic properties of pristine- and defective-BaZrO_3−δ show consistency with oxygen vacancy concentration. A comparison of predicted thermochemical properties with and without explicit vibrational corrections demonstrates their relative stability and implications at high-temperatures, as reduction Gibbs free energies in BaZrO_3−δ exhibit large deviations above 1000 K. We elucidate the physical origins of these deviations via a phonon mode analysis.]]> Mon 22 Jun 2020 13:28:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:18696 Mon 20 Jul 2015 17:48:34 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:45818 Mon 07 Nov 2022 12:18:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:36056 Mon 03 Feb 2020 11:52:08 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:41279 Mon 01 Aug 2022 10:24:24 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:32593 Fri 22 Jun 2018 14:57:22 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:40033 Fri 15 Jul 2022 10:11:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:36560 Fri 05 Jun 2020 20:10:17 AEST ]]>