https://nova.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Posttraumatic stress disorder among deliberate self-poisoning patients https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:15322 Wed 11 Apr 2018 17:07:37 AEST ]]> Cognitive skills underlying driving in patients discharged following self-poisoning with central nervous system depressant drugs https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:11542 Wed 11 Apr 2018 15:09:26 AEST ]]> Risk of road traffic accidents in patients discharged following treatment for psychotropic drug overdose: a self-controlled case series study in Australia https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:11591 Wed 11 Apr 2018 13:56:10 AEST ]]> A pharmacological approach to first aid treatment for snakebite https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:14381 Wed 11 Apr 2018 10:04:10 AEST ]]> Effectiveness of the Hunter Way Back Support Service: An historical controlled trial of a brief non-clinical after-care program for hospital-treated deliberate self-poisoning https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:48001 Tue 14 Feb 2023 16:42:54 AEDT ]]> A review of ECG and QT interval measurement use in a public psychiatric inpatient setting https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:36283 Thu 19 Mar 2020 17:51:33 AEDT ]]> Clinical and ECG effects of escitalopram overdose https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:8129 Sat 24 Mar 2018 08:40:04 AEDT ]]> Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:1898 440 msec. Results: There were 469 SSRI poisoning admissions analyzed after exclusions. The median LOS for all SSRI overdose admissions was 15.3 h (IQR: 10.5–21.3) and 30 of 469 (6.4%; 95% CI 4.3–9.0%) cases were admitted to ICU. The incidence of seizures was 1.9% and coma was 2.4%. Serotonin syndrome occurred in 14% of overdoses. Comparison of median QTc intervals of the five SSRIs was significantly different (p = 0.0002); citalopram (450 IQR: 436–484) was individually different to fluoxetine (p = 0.045), fluvoxamine (p = 0.022), paroxetine (p = 0.0002), and sertraline (p = 0.001). The proportion of citalopram overdoses with a QTc > 440 msec was 68%, differing significantly from sertraline (adjusted OR: 5.11 95% CI 2.32–11.27). Comparison of median QT intervals of the five SSRIs was statistically different (p = 0.026); citalopram (400 IQR: 380–440) was individually different from sertraline (p = 0.023). Conclusions: This study shows SSRIs are relatively safe in overdose despite serotonin syndrome being common. The exception was citalopram, which was significantly associated with QTc prolongation. We believe that cardiac monitoring should be considered in citalopram overdose, particularly with large ingestions and patients with associated cardiac disease.]]> Sat 24 Mar 2018 08:33:08 AEDT ]]> Postcards from the EDge project: randomised controlled trial of an intervention using postcards to reduce repetition of hospital treated deliberate self poisoning https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:2460 Sat 24 Mar 2018 08:27:47 AEDT ]]> Life-threatening hypokalaemia associated with ibuprofen-induced renal tubular acidosis https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:14870 Sat 24 Mar 2018 08:21:10 AEDT ]]> Postcards from the EDge: 5-year outcomes of a randomised controlled trial for hospital-treated self-poisoning https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:18226 Sat 24 Mar 2018 08:04:52 AEDT ]]> Postcards from the EDge: 24-Month outcomes of a randomised controlled trial for hospital-treated self-poisoning https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:5783 Sat 24 Mar 2018 07:44:56 AEDT ]]> Sodium azide ingestion and secondary contamination risk in healthcare workers https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:25949 Sat 24 Mar 2018 07:41:24 AEDT ]]> Population pharmacokinetic-pharmacodynamic modelling to describe the effects of paracetamol and N-acetylcysteine on the international normalized ratio https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:27173 Sat 24 Mar 2018 07:31:43 AEDT ]]> Implementation of a centralised aminoglycoside monitoring service https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:23087 Sat 24 Mar 2018 07:12:34 AEDT ]]> A prospective observational study of a novel 2-phase infusion protocol for the administration of acetylcysteine in paracetamol poisoning https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:23068 1000 U/L or abnormal ALT. Results: 654 paracetamol poisonings were treated with the new protocol; median age 29 y (15-98 y); 453 females; 576 acute and 78 staggered/chronic ingestions. In 420 (64%) acetylcysteine was stopped for low-risk paracetamol concentrations. An adverse reaction occurred in 229/654 admissions (35%; 95% CI: 31-39%): 173 (26.5%; 95% CI: 23-30%) only gastrointestinal, 50 (8%; 95% CI: 6-10%) skin only systemic hypersensitivity reactions; and three severe anaphylaxis (0.5%; 95% CI: 0.1-1.5%; all hypotension). Adverse reactions occurred in 111/231 (48%) receiving full treatment compared to 116/420 (28%) in whom the infusion was stopped early (absolute difference 20%; 95% CI: 13-28%; p < 0.0001). In 200 overdoses < 10 g, one had toxic paracetamol concentrations, but 53 developed reactions. Sixteen patients had an ALT > 1000 U/L and 24 an abnormal ALT attributable to paracetamol; all but one had treatment commenced >12 h post-ingestion. Conclusion: A 2-phase acetylcysteine infusion protocol results in a fewer reactions in patients with toxic paracetamol concentrations, but is not justified in patients with low-risk paracetamol concentrations.]]> Sat 24 Mar 2018 07:12:28 AEDT ]]> A prospective cohort study of trends in self-poisoning, Newcastle, Australia, 1987-2012: plus ça change, plus c'est la même chose https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:24683 Sat 24 Mar 2018 07:10:55 AEDT ]]> Comparison of accredited person and medical officer discharge decisions under the Mental Health Act of NSW: A cohort study of deliberate self-poisoning patients https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:44730 Mon 24 Oct 2022 08:28:51 AEDT ]]> Hospital-treated deliberate self-poisoning patients: Drug-induced delirium and clinical outcomes https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:44561 Mon 17 Oct 2022 10:20:23 AEDT ]]> Use of a tablet-based application for clinical handover and data collection https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:41233 Fri 29 Jul 2022 14:02:23 AEST ]]>