https://nova.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Physical Activity as a Predictor of Clinical Trial Outcomes in Bipolar Depression: A Subanalysis of a Mitochondrial-Enhancing Nutraceutical Randomized Controlled Trial https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:46788 Wed 30 Nov 2022 13:21:42 AEDT ]]> Personality disorder and functioning in major depressive disorder: A nested study within a randomized controlled trial https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:45277 0.14). Conclusion: In this secondary analysis of a primary efficacy study, PD was a common comorbidity among those with MDD, but was not a significant predictor of functional outcomes. This study adds to the limited literature on PD in randomized controlled trials for MDD.]]> Wed 26 Oct 2022 17:13:15 AEDT ]]> Personality disorder increases risk of low quality of life among women with mental state disorders https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:45043 n = 717) were administered the Structured Clinical Interview for DSM-IV (SCID-I/NP and SCID-II) and the World Health Organisation Quality of Life scale (WHOQOL-BREF). Weight and height were measured and lifestyle and demographic factors were self-reported. Logistic regression models (odds ratios with 95% confidence intervals) were undertaken to investigate associations among groups (mental state disorders, co-occurring mental state disorders with PD, and controls) and the WHOQOL-BREF domains (physical, psychological, social, and environmental health) while testing for potential confounding. Results: Results indicated that mental state disorders were associated with increased risk of low quality of life in physical, psychological, social, but not environmental domains, compared to controls. This risk was increased among women with co-occurring PD across all domains compared to both controls and those with mental state disorders. Conclusion: These findings add evidence suggesting poor quality of life is experienced by those with mental state disorders, and that this is worsened by the experience of co-occurring PD.]]> Wed 26 Oct 2022 12:00:30 AEDT ]]> A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochondrial agents, N-acetylcysteine, and placebo https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:36597 Wed 10 Jun 2020 15:12:41 AEST ]]> The Added Burden of Personality Disorder on Subsidized Australian Health Service Utilization Among Women With Mental State Disorder https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:53737 Wed 10 Jan 2024 11:31:34 AEDT ]]> Systematic review and meta-analysis of the role of personality disorder in randomised controlled trials of pharmacological interventions for adults with mood disorders https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:39815 I2 statistic. This systematic review was registered with PROSPERO (CRD42018089279) and the protocol is published. Results: The search yielded 11,640 studies. Subsequent to removing duplicates, 9657 studies were screened at title and abstract stage and 1456 were assessed at full-text stage. Eighteen studies met criteria for inclusion in this review. Meta-analysis did not reveal a significant difference between groups for treatment outcome (standardised mean difference 0.22 [-0.09, 0.54]; I2: 69%, p=0.17) and remission (risk ratio 0.84 [0.64, 1.11]; I2: 51%, p=0.22). Limitations: This review was limited by lack of studies on bipolar disorder. Conclusion: PD comorbidity does not appear to affect treatment efficacy of pharmacological interventions for adults with mood disorders.]]> Wed 10 Aug 2022 13:16:51 AEST ]]> Attachment insecurity partially mediates the relationship between childhood trauma and depression severity in bipolar disorder https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:53619 Wed 07 Feb 2024 14:40:08 AEDT ]]> The influence of childhood trauma on the treatment outcomes of pharmacological and/or psychological interventions for adolescents and adults with bipolar disorder: A systematic review and meta-analysis https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:50157 Wed 05 Jul 2023 15:21:49 AEST ]]> Baseline serum amino acid levels predict treatment response to augmentation with N-acetylcysteine (NAC) in a bipolar disorder randomised trial https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:50150 50% at baseline). Untargeted gas chromatography–mass spectrometry analysis was performed to analyse baseline levels of 68 serum metabolites. Of the nine metabolites that differentiated placebo and NAC groups, five were amino acids with lower levels in the NAC responder group compared with the NAC non-responders. Further analysis generated a predictive model of MADRS improvement including glycine, norleucine, threonine, proline, phenylalanine, tyrosine, glutamic acid, lysine and leucine (R2 = 0.853; adjusted R2 = 0.733). This prediction model predicted 85% of the variance in MADRS outcome after adjunctive treatment with NAC. BD participants with lower serum levels of free amino acids at baseline may be more likely to respond to adjunctive treatment with NAC.]]> Wed 05 Jul 2023 14:11:36 AEST ]]> N-acetylcysteine (NAC) for methamphetamine dependence: A randomised controlled trial https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:48692 Tue 28 Mar 2023 20:45:40 AEDT ]]> The effect of emerging nutraceutical interventions for clinical and biological outcomes in multiple sclerosis: A systematic review https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:39853 Tue 26 Jul 2022 10:28:34 AEST ]]> Interpersonal Trauma and Depression Severity Among Individuals With Bipolar Disorder: Findings From the Prechter Longitudinal Study of Bipolar Disorder https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:51126 Tue 22 Aug 2023 15:51:43 AEST ]]> Personality traits as mediators of the relationship between childhood trauma and depression severity in bipolar disorder: A structural equation model https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:51127 Tue 22 Aug 2023 15:51:17 AEST ]]> The Impact of Posttraumatic Stress Disorder on Pharmacologic Intervention Outcomes for Adults With Bipolar Disorder: A Systematic Review https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:51427 Tue 05 Sep 2023 17:47:47 AEST ]]> Measuring cognitive insight in people with problematic substance use: an exploration of the factor validity of the Beck Cognitive Insight Scale https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:38082 2[22, n = 312] = 76.43, P ' 0.02). Internal consistency analyses indicated acceptable internal reliability (Self-Reflection a = 0.73, Self-Certainty a = 0.72, composite a = 0.75). Self-Certainty scores were significantly higher for participants with a self-reported psychotic disorder (M = 14.95 vs. M = 13.04, P = 0.007). Self-Reflection scores were higher for people experiencing psychological distress (M = 17.57 vs. M = 15.95, P = 0.001). Discussion and Conclusions: We found that a 12-item version of the BCIS had good psychometric properties in this substance-using population. Further research is needed to explore whether insight can predict treatment outcomes for substance use.]]> Tue 03 Aug 2021 18:14:35 AEST ]]> Cognitive insight, medication adherence and methamphetamine cessation in people enrolled in a pharmacotherapy trial for methamphetamine use https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:38081 Tue 03 Aug 2021 18:14:34 AEST ]]> Diagnostic accuracy for self-reported methamphetamine use versus oral fluid test as the reference standard in a methamphetamine-dependent intervention trial population https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:50837 Thu 17 Aug 2023 11:53:14 AEST ]]> Design and rationale of a 16-week adjunctive randomized placebo-controlled trial of mitochondrial agents for the treatment of bipolar depression https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:26171 Sat 24 Mar 2018 07:30:06 AEDT ]]> Adjunctive Garcinia mangostana Linn. (Mangosteen) Pericarp for Schizophrenia: A 24-Week Double-blind, Randomized, Placebo Controlled Efficacy Trial https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:49523 Sat 20 May 2023 12:39:02 AEST ]]> A potential role for N-acetylcysteine in the management of methamphetamine dependence (commentary) https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:27031 Mon 23 Sep 2019 12:39:49 AEST ]]> Diet quality, dietary inflammatory index and body mass index as predictors of response to adjunctive N-acetylcysteine and mitochondrial agents in adults with bipolar disorder: a sub-study of a randomised placebo-controlled trial https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:39177 n = 133). Participants received 16 weeks adjunctive treatment of either placebo or N-acetylcysteine-alone or a combination of mitochondrial-enhancing nutraceuticals including N-acetylcysteine (combination treatment). Participants were followed up 4 weeks post-treatment discontinuation (Week 20). Diet was assessed by the Cancer Council Victoria Dietary Questionnaire for Epidemiological Studies, Version 2, converted into an Australian Recommended Food Score to measure diet quality, and energy-adjusted dietary inflammatory index score to measure inflammatory potential of diet. Body mass index was also measured. Generalised estimating equation models were used to assess whether diet quality, energy-adjusted dietary inflammatory index score and/or body mass index were predictors of response to significant outcomes of the primary trial: depression symptoms, clinician-rated improvement and functioning measures. Results: In participants taking combination treatment compared to placebo, change in depression scores was not predicted by Australian Recommended Food Score, dietary inflammatory index or body mass index scores. However, participants with better diet quality (Australian Recommended Food Score) reported reduced general depression and bipolar depression symptoms (p = 0.01 and p = 0.03, respectively) and greater clinician-rated improvement (p = 0.02) irrespective of treatment and time. Participants who had a more anti-inflammatory dietary inflammatory index had less impairment in functioning (p = 0.01). Combination treatment may attenuate the adverse effects of pro-inflammatory diet (p = 0.03) on functioning. Participants with lower body mass index who received combination treatment (p = 0.02) or N-acetylcysteine (p = 0.02) showed greater clinician-rated improvement. Conclusion: These data support a possible association between diet (quality and inflammatory potential), body mass index and response to treatment for bipolar depression in the context of a nutraceutical trial. The results should be interpreted cautiously because of limitations, including numerous null findings, modest sample size and being secondary analyses.]]> Mon 23 May 2022 14:53:36 AEST ]]> Clinical and demographic characteristics of people who smoke versus inject crystalline methamphetamine in Australia: Findings from a pharmacotherapy trial https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:49563 0.05). After adjustment for demographic differences, participants who smoked had lower craving [b (SE) = −1.1 (0.5), P = 0.021] and were less likely to report psychotic symptoms [b (SE) = −1.8 (0.7), P = 0.013] or antidepressant use [b (SE) = −1.1 (0.5), P = 0.022]. Discussion and Conclusions: Smoking crystalline methamphetamine is associated with a younger less marginalised demographic profile than injecting methamphetamine, but a similarly severe clinical profile.]]> Mon 22 May 2023 09:20:09 AEST ]]> Does Post-traumatic Stress Disorder Impact Treatment Outcomes within a Randomised Controlled Trial of Mitochondrial Agents for Bipolar Depression? https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:52335 Mon 09 Oct 2023 14:50:31 AEDT ]]> Childhood trauma and depressive symptoms in bipolar disorder: A network analysis https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:51396 Mon 04 Sep 2023 14:43:02 AEST ]]> Exploring interleukin-6, lipopolysaccharide binding protein and brain-derived neurotrophic factor following 12 weeks of adjunctive minocycline treatment for depression https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:51700 Fri 15 Sep 2023 10:39:15 AEST ]]> Insight in substance use disorder: A systematic review of the literature https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:41579 Fri 05 Aug 2022 14:44:41 AEST ]]> Mixed Methods Thematic Analysis of a Randomised Controlled Trial of Adjunctive Mitochondrial Agents for Bipolar Depression https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:51362 Fri 01 Sep 2023 13:44:30 AEST ]]>