https://nova.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:37387 2 and (Mo,W)S₂ by using supercritical water with organic reducing agents from simple and less-toxic precursors. This synthesis process is expected to be suitable for preparing other various kinds of TMD solid solutions.]]> Wed 28 Oct 2020 18:33:01 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:34062 Wed 24 Jul 2019 12:58:07 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:29882 gem-dimethyl group), the RCEDYM reaction leads to 14,15-isotaxanes 16 a,b and 18 b with the gem-dimethyl group on the A ring. If the alkyne is at the C11 position (and thus flanked by a gem-dimethyl group), RCEDYM reaction only proceeds in the presence of a trisubstituted olefin at C13, which disfavors the competing diene ring-closing metathesis reaction, to give the tricyclic core of Taxol 44.]]> Wed 11 Apr 2018 11:08:27 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:22766 Wed 11 Apr 2018 10:54:34 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:6804 Wed 11 Apr 2018 10:49:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:50142 20 nm). The inability to precisely control nanoparticle crystallinity, size, and shape has significant implications on observed properties and therefore applications. A series of iron oxide particles have been synthesised and the impact of size as they agglomerate in aqueous media undergoing flow through a capillary tube has been studied. Reaction conditions for the production of large (side length > 40 nm) cubic magnetite (Fe3O4) have been optimised to produce particles with different diameters up to 150 nm. We have focussed on reproducibility in synthesis rather than dispersity of the size distribution. A simple oxidative cleavage of the as-synthesised particles surfactant coating transforms the hydrophobic oleic acid coated Fe3O4 to a hydrophilic system based on azelaic acid. The hydrophilic coating can be further functionalised, in this case we have used a simple biocompatible polyethylene glycol (PEG) coating. The ability of particles to either chain, flow, and fully/or partially aggregate in aqueous media has been tested in a simple in-house system made from commercial components. Fe3O4 nanoparticles (60-85 nm) with a simple PEG coating were found to freely flow at a 2 mm distance from a magnet over 3 min at a rate of 1 mL min-1. Larger particles with side lengths of ∼150 nm, or those without a PEG coating were not able to fully block the tube. Simple calculations have been performed to support these observations of magnetic agglomeration.]]> Wed 05 Jul 2023 13:08:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:34681 B. subtilis 168 and MRSA USA300) and Gram-negative bacteria (P. aer PAO1 and A. baum ATCC19606) in vitro, the derivatives exhibited good antibacterial activity, particularly against Gram-positive bacteria with an minimum inhibitory concentrations (MIC) value of 2–16 µg/mL. The subsequent synergistic antibacterial assay showed that derivatives 5c and 6c enhanced the susceptibility of B. subtilis 168 and MRSA USA300 to chloramphenicol (CHL) and kanamycin (KAN) (FICI < 0.5). Our data showed that ocotillol-type derivatives with long-chain amino acid substituents at C-3 were good leads against antibiotic-resistant pathogens MRSA USA300, which could improve the ability of KAN and CHL to exhibit antibacterial activity at much lower concentrations with reduced toxicity.]]> Wed 04 Sep 2019 10:06:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:47922 Thu 09 Feb 2023 10:42:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:7775 Sat 24 Mar 2018 10:48:04 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:8246 Sat 24 Mar 2018 08:40:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:9530 Sat 24 Mar 2018 08:35:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:1346 Sat 24 Mar 2018 08:32:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:1663 50 : 1 noted. All analogues were screened for their ability to interact with CRH₁ and CRH₂ receptors. In all instances only poor agonistic and/or antagonistic behaviour was noted at CRH₂. However, several compounds were potent and selective CRH₁ antagonists, most notably 13a Ki = 39nM. Additionally we have utilized these data and that recently reported by others to refine our original CRH₁ pharmacophore.]]> Sat 24 Mar 2018 08:30:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:15319 3(DAMT)₂(DAMTH)₂cl₈] have been prepared and identified by elemental analyses, infrared, Raman, ¹H and ¹³C NMR spectroscopy, and a single crystal X-ray diffraction. The protonation equilibria of the ligand have been studied by pH-potentiometry, with pK₁ 13.29 and pK₂ 5.40 determined. The free ligand consists of triazole cations (DAMTH) and chloride counter ions. The neutral cadmium compound is a complex of the cationic ligand in which 3Cd's are coordinated by two unidentate cation forms of the ligands (DAMTH), two ambidentate neutral forms of the ligand (DAMT), and eight chlorides. Cadmium ions have slightly distorted octahedral geometry.]]> Sat 24 Mar 2018 08:26:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:9983 Sat 24 Mar 2018 08:14:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:10416 Sat 24 Mar 2018 08:12:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:19942 Sat 24 Mar 2018 07:58:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:17936 Sat 24 Mar 2018 07:56:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:20625 Sat 24 Mar 2018 07:55:46 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:18787 50) of 42 μM in MCF-7 (breast) cells and 24 μM in A2780 (ovarian) cells and >50 μM in all other cell lines tested. The development of eight focused libraries comprising thirty compounds total identified N-(biphenyl-4-ylmethyl)-1H-pyrrole-2-carboxamide (4l), N-benzyl-4,5-dibromo-1H-pyrrole-2-carboxamide (5a) and N-(biphenyl-4-ylmethyl)-4,5-dibromo-1H-pyrrole-2-carboxamide (5l) as potent inhibitors of cell growth in our panel of cell lines. Of these compounds GI₅₀ values of <5 μM were observed with 4l against HT29 (colon) and SW480 (colon); 5a against HT29; and 5l against HT29, SW480, MCF-7, A431 (skin), Du145 (prostate), BE2-C (neuroblastoma) and MIA (pancreas) cell lines. As a cancer class, colon cancer appears to be more sensitive to the oroidin series of compounds, with analogue 5l being the most active.]]> Sat 24 Mar 2018 07:51:02 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:18534 Sat 24 Mar 2018 07:50:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:27729 Sat 24 Mar 2018 07:36:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:22223 100 μM), as per the parent molecule. We also discovered that the introduction of a terminal phosphate moiety (28) at the same position produced a different trend in cytotoxicity with strong activity in BE2-C (neuroblastoma; GI₅₀ = 9 μM) cells; suggestive of an alternate mode of action.]]> Sat 24 Mar 2018 07:17:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:22226 Sat 24 Mar 2018 07:17:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:37093 Mon 17 Aug 2020 12:34:44 AEST ]]>