https://nova.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Being in limbo: the experience of critical illness in intensive care and beyond https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:15298 Wed 11 Apr 2018 15:43:38 AEST ]]> Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:50847 Wed 09 Aug 2023 09:32:29 AEST ]]> Compliance phenotypes in early acute respiratory distress syndrome before the COVID-19 pandemic https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:41102 Tue 26 Jul 2022 14:20:11 AEST ]]> Conservative oxygen therapy during mechanical ventilation in the ICU https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:48262 2) and have a high arterial oxygen tension. The conservative use of oxygen may reduce oxygen exposure, diminish lung and systemic oxidative injury, and thereby increase the number of ventilator-free days (days alive and free from mechanical ventilation). Methods: We randomly assigned 1000 adult patients who were anticipated to require mechanical ventilation beyond the day after recruitment in the ICU to receive conservative or usual oxygen therapy. In the two groups, the default lower limit for oxygen saturation as measured by pulse oximetry (Spo₂) was 90%. In the conservativeoxygen group, the upper limit of the Spo₂ alarm was set to sound when the level reached 97%, and the Fio2 was decreased to 0.21 if the Spo₂ was above the acceptable lower limit. In the usual-oxygen group, there were no specific measures limiting the Fio₂ or the Spo₂. The primary outcome was the number of ventilator-free days from randomization until day 28. Results: The number of ventilator-free days did not differ significantly between the conservative-oxygen group and the usual-oxygen group, with a median duration of 21.3 days (interquartile range, 0 to 26.3) and 22.1 days (interquartile range, 0 to 26.2), respectively, for an absolute difference of -0.3 days (95% confidence interval [CI], -2.1 to 1.6; P = 0.80). The conservative-oxygen group spent more time in the ICU with an Fio2 of 0.21 than the usual-oxygen group, with a median duration of 29 hours (interquartile range, 5 to 78) and 1 hour (interquartile range, 0 to 17), respectively (absolute difference, 28 hours; 95% CI, 22 to 34); the conservative-oxygen group spent less time with an Spo₂ exceeding 96%, with a duration of 27 hours (interquartile range, 11 to 63.5) and 49 hours (interquartile range, 22 to 112), respectively (absolute difference, 22 hours; 95% CI, 14 to 30). At 180 days, mortality was 35.7% in the conservative-oxygen group and 34.5% in the usual-oxygen group, for an unadjusted odds ratio of 1.05 (95% CI, 0.81 to 1.37). Conclusions: In adults undergoing mechanical ventilation in the ICU, the use of conservative oxygen therapy, as compared with usual oxygen therapy, did not significantly affect the number of ventilator-free days.]]> Tue 21 Mar 2023 17:42:53 AEDT ]]> Being in limbo: the experience of critical illness in intensive care and beyond https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:12231 Thu 11 Jul 2019 14:52:21 AEST ]]> Quetiapine overdose: predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:7015 Sat 24 Mar 2018 08:38:04 AEDT ]]> Factors that impact on sleep in intensive care patients https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:7235 Sat 24 Mar 2018 08:33:45 AEDT ]]> The experience of communication difficulties in critically ill patients in and beyond intensive care: findings from a larger phenomenological study https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:27060 Sat 24 Mar 2018 07:25:21 AEDT ]]> Education of ICU nurses regarding invasive mechanical ventilation: findings from a cross-sectional survey https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:22577 Sat 24 Mar 2018 07:15:56 AEDT ]]> Intensive care nurses’ perceptions of the continuing education regarding mechanical ventilation at a major regional tertiary-referral hospital in Australia https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:33447 Mon 23 Sep 2019 13:51:40 AEST ]]> Selective digestive tract decontamination in critically ill adults with acute brain injuries: a post hoc analysis of a randomized clinical trial https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:54600 Mon 04 Mar 2024 09:10:35 AEDT ]]>