https://nova.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Effects of prenatal stress on fetal neurodevelopment and responses to maternal neurosteroid treatment in guinea pigs https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:16551 Wed 11 Apr 2018 17:05:24 AEST ]]> Asthma exacerbations during pregnancy: incidence and association with adverse pregnancy outcomes https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:1226 Wed 11 Apr 2018 16:52:40 AEST ]]> Changes in neuroactive steroid concentrations after preterm delivery in the guinea pig https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:16517 Wed 11 Apr 2018 16:11:20 AEST ]]> Impact of periconceptional and preimplantation undernutrition on factors regulating myogenesis and protein synthesis in muscle of singleton and twin fetal sheep https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:27351 Wed 11 Apr 2018 13:32:44 AEST ]]> Fetal programming in 2-year-old calving heifers: peri-conception and first trimester protein restriction alters fetal growth in a gender-specific manner https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:17477 0.1). At term, no dietary effect on birthweight was observed (P > 0.1) and males were not heavier than females (P > 0.1). These results suggest that maternal protein intake during the peri-conception (-60 to 23dpc) and first trimester (24-98dpc) may influence early conceptus growth and development in the bovine. The long-term effects on offspring metabolism and post-natal development of this dietary intervention are yet to be determined. © CSIRO 2014.]]> Wed 11 Apr 2018 09:22:40 AEST ]]> Loss of neurosteroid-mediated protection following stress during fetal life https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:24307 A receptor subunits that normally heighten neurosteroid sensitivity. These stressors also result in altered placental allopregnanolone metabolism pathways. These findings suggest that reduced neurosteroid production and action in the perinatal period may contribute to some of the adverse neurodevelopmental and behavioural outcomes that result from these pregnancy compromises. Studies examining perinatal steroid supplementation therapy with non-metabolisable neurosteroid analogues to improve these outcomes are warranted.]]> Thu 21 Oct 2021 12:51:39 AEDT ]]> Injury of the developing cerebellum: a brief review of the effects of endotoxin and asphyxial challenges in the late gestation sheep fetus https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:16534 Thu 21 Jul 2022 15:38:24 AEST ]]> Greater maternal weight gain during pregnancy predicts a large but lean fetal phenotype: a prospective cohort study https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:12933 Sat 24 Mar 2018 10:36:37 AEDT ]]> Asthma in pregnancy https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:8664 Sat 24 Mar 2018 08:38:43 AEDT ]]> Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:7900 Sat 24 Mar 2018 08:35:11 AEDT ]]> Stress in pregnancy activates neurosteroid production in the fetal brain https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:986 A receptor and suppress the fetal CNS activity. These steroids are synthesized in the fetal brain either from cholesterol or from circulating precursors derived from the placenta. The concentrations of allopregnanolone are remarkably high in the fetal brain and rise further in response to acute hypoxic stress, induced by constriction of the umbilical cord. This response may result from the increased 5α-reductase and cytochrome P-450SCC expression in the brain. These observations suggest that the rise in neurosteroid concentrations in response to acute hypoxia may represent an endogenous protective mechanism that reduces excitotoxicity following hypoxic stress in the developing brain. In contrast to acute stress, chronic hypoxemia induces neurosteroidogenic enzyme expression without an increase in neurosteroid concentrations and, therefore, may pose a greater risk to the fetus. At birth, the allopregnanolone concentrations in the brain fall markedly, probably due to the loss of placental precursors; however, stressors, including hypoxia and endotoxin-induced inflammation, raise allopregnanolone concentrations in the newborn brain. This may protect the newborn brain from hypoxia-induced damage. However, the rise in allopregnanolone concentrations was also associated with increased sleep. This rise in sedative steroid levels may depress arousal and contribute to the risk of sudden infant death syndrome. Our recent findings indicate that acute hypoxic stress in pregnancy initiates a neurosteroid response that may protect the fetal brain from hypoxia-induced cell death, whereas the decline in allopregnanolone levels after birth may result in greater vulnerability to brain injury in neonates.]]> Sat 24 Mar 2018 08:29:48 AEDT ]]> Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:20824 Sat 24 Mar 2018 08:05:56 AEDT ]]> Embryo number and periconceptional undernutrition in the sheep have differential effects on adrenal epigenotype, growth, and development https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:20508 Sat 24 Mar 2018 07:59:05 AEDT ]]> Differential effects of maternal obesity and weight loss in the periconceptional period on the epigenetic regulation of hepatic insulin-signaling pathways in the offspring https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:19725 P<0.05), miR-103 (P<0.01), and miR-107 (P<0.05) expression, a decrease in IR (P<0.05), phopsho- Akt (P<0.01), and phospho-FoxO1 (P<0.01) abundance, and a paradoxical decrease in 11ßHSD1 (P<0.05), PEPCK-C (P<0.01), and PEPCK-M (P<0.05) expression in lambs. These changes were ablated by a period of moderate dietary restriction imposed during the periconceptional period. Maternal dietary restriction alone also resulted in decreased abundance of a separate subset of hepatic insulin-signaling molecules, namely, IRS1 (P<0.05), PDK1 (P<0.01), phospho-PDK1 (P<0.05), and aPKCζ (P<0.05) and in decreased PEPCK-C (P<0.01) and G6Pase (P<0.01) expression in the lamb. Our findings highlight the sensitivity of the epigenome to maternal nutrition around conception and the need for dietary interventions that maximize metabolic benefits and minimize metabolic costs for the next generation.-Nicholas, L. M., Rattanatray, L., MacLaughlin, S. M., Ozanne, S. E., Kleemann, D. O.,Walker, S. K., Morrison, J. L., Zhang, S., Muhlhausler, B. S., Martin-Gronert, M. S., McMillen, I. C. Differential effects of maternal obesity and weight loss in the periconceptional period on the epigenetic regulation of hepatic insulin-signaling pathways in the offspring.]]> Sat 24 Mar 2018 07:53:44 AEDT ]]> Periconceptional undernutrition programs changes in insulin-signaling molecules and microRNAs in skeletal muscle in singleton and twin fetal sheep https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:20984 Sat 24 Mar 2018 07:50:31 AEDT ]]> Models of perinatal compromises in the guinea pig: their use in showing the role of neurosteroids in pregnancy and the newborn https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:29502 Sat 24 Mar 2018 07:29:45 AEDT ]]> Neurosteroids in the fetus and neonate: potential protective role in compromised pregnancies https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:4813 Sat 24 Mar 2018 07:20:45 AEDT ]]> Fetal effects of environmental exposure of pregnant women to organophosphorus compounds in a rural farming community in Sri Lanka https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:4770 Sat 24 Mar 2018 07:20:38 AEDT ]]> Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:44727 Mon 24 Oct 2022 08:12:40 AEDT ]]> Assessment of fetal kidney growth and birth weight in an Indigenous Australian cohort https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:32049 Mon 23 Sep 2019 11:46:34 AEST ]]> Systematic review with meta-analysis: autoimmune hepatitis in pregnancy https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:48637 Fri 24 Mar 2023 13:23:48 AEDT ]]>