https://nova.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:46481 Wed 24 May 2023 13:04:59 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:51041 Wed 16 Aug 2023 10:37:28 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:19281 Wed 11 Apr 2018 16:09:34 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:17231 K,L. A similar current was first observed at 15 WG but remained relatively small, even at 18 WG. The presence of a “collapsing” tail current indicates a maturing type I hair cell phenotype and suggests the presence of a surrounding calyx afferent terminal. We were also able to record from calyx afferent terminals in 15–18 WG cristae. In voltage clamp, these terminals exhibited fast inactivating inward as well as slower outward conductances, and in current clamp, discharged a single action potential during depolarizing steps. Together, these data suggest the major functional characteristics of type I and type II hair cells and calyx terminals are present by 18 WG. Our study also describes a new preparation for the functional investigation of key events that occur during maturation of human vestibular organs.]]> Wed 11 Apr 2018 14:41:28 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:6901 Wed 11 Apr 2018 12:50:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:6899 Wed 11 Apr 2018 10:30:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:15926 Wed 11 Apr 2018 10:07:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:21950 Wed 11 Apr 2018 09:46:58 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:1879 Sat 24 Mar 2018 08:31:19 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:1186 Sat 24 Mar 2018 08:28:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:12355 Sat 24 Mar 2018 08:18:31 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:13247 Sat 24 Mar 2018 08:16:00 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:12308 Sat 24 Mar 2018 08:11:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:11513 Sat 24 Mar 2018 08:11:08 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:19402 Sat 24 Mar 2018 07:52:08 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:21361 Sat 24 Mar 2018 07:51:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:23550 Sat 24 Mar 2018 07:14:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:52855 92%). Short-term plasticity was studied by examining discharge rate modulation following release from hyperpolarization [postinhibitory rebound firing (PRF)] and depolarization [firing rate adaptation (FRA)]. PRF and FRA gain were similar in Deiters’ and non-Deiters’ neurons (PRF 24.9 vs. 20.2 Hz and FRA gain 231.5 vs. 287.8 spikes/s/nA, respectively). Inhibitory synaptic input to both populations showed that GABAergic rather than glycinergic inhibition dominated. However, GABAA miniature inhibitory postsynaptic current (mIPSC) frequency was much higher in Deiters’ neurons compared with non-Deiters’ neurons (∼15.9 vs. 1.4 Hz, respectively). Our data suggest that Deiters’ neurons can be reliably identified by their intrinsic membrane and synaptic properties. They are tonically active and glutamatergic, have low sensitivity or “gain,” exhibit little adaptation, and receive strong GABAergic input. Deiters’ neurons also have minimal short-term plasticity, and together these features suggest they are well suited to a role in encoding tonic signals for the vestibulospinal reflex. New & Noteworthy: Deiters’ neurons within the lateral vestibular nucleus project the length of the spinal cord and activate antigravity extensor muscles. Deiters’ neurons were characterized anatomically and physiologically in mice. Deiters’ neurons are tonically active, have homogeneous intrinsic membrane properties, including low input resistance, and receive significant GABAAergic synaptic inputs. Deiters’ neurons show little modulation in response to current injection. These features are consistent with Deiters’ neurons responding to perturbations to maintain posture and balance.]]> Mon 30 Oct 2023 09:54:00 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:50957 Mon 14 Aug 2023 15:10:54 AEST ]]>