${session.getAttribute("locale")} 5 Somatic copy number amplification and hyperactivating somatic mutations of EZH2 correlate with DNA methylation and drive epigenetic silencing of genes involved in tumor suppression and immune responses in melanoma Tue 22 Aug 2017 15:31:47 EST ]]> Evaluation of immune-related response criteria and RECIST v1.1 in patients with advanced melanoma treated with pembrolizumab Tue 22 Aug 2017 15:24:46 EST ]]> Incidence and risk factors for type 2 diabetes mellitus in transitional Thailand: results from the Thai cohort study Tue 22 Aug 2017 15:03:52 EST ]]> Of monkeys and men: impatience in perceptual decision-making Tue 22 Aug 2017 15:03:49 EST ]]> Effects of a community-based salt reduction program in a regional Australian population Tue 22 Aug 2017 15:03:48 EST ]]> New visions in space-time: architecture and photography in the experimental photo-practice of Moholy-nagy Tue 22 Aug 2017 14:59:24 EST ]]> The complete oxidation of isobutane over CeO2 and Au/CeO2, and the composite catalysts MOx/CeO2 and Au/MOx/CeO2 (Mn+ = Mn, Fe, Co and Ni): the effects of gold nanoparticles obtained from n-hexanethiolate-stabilized gold nanoparticles x/CeO₂ and Au/MOx/CeO₂, where M = Mn, Fe, Co and Ni, using a range of CeO₂ surface areas. The catalytic ability of CeO₂ depended on the specific surface area, and the addition of gold always increased activity. Similarly, addition of MOx to CeO₂ (M:Ce = 1:10) increased catalytic activity, and there was a synergic interaction between the MOx and CeO₂ phases. For Au/MOx/CeO₂ catalysts the presence of gold nanoparticles did not affect the initial reaction temperature or that for 100% conversion, or the apparent activation energy compared to MOx/CeO₂ catalysts. The rate determining step in these reactions is suggested to be C—H bond activation. This was supported by TG/DTA studies under 10% H₂ in N₂ that showed there was no correlation between the catalysis results and the temperature of initial mass loss of lattice oxygen. Gold nanoparticles (5 wt%) were introduced by adsorption and subsequent thermolysis of preformed n-hexanethiolate-stabilized gold nanoparticles. STEM and XRD studies showed that the average size of the gold nanoparticles depended on the surface area. Introduction of gold nanoparticles by this method introduces a small amount of sulfur as adsorbed sulfate, but this did not have any major poisoning effect on isobutane oxidation. Gold 4f7/2 XPS studies on Au/MOx/CeO₂ showed that the only common gold species was Au(0), suggesting that higher oxidation states were not important in the oxidation, while Ce 3d5/2 studies established the presence of Ce(III) in addition to Ce(IV), indicating their involvement in the Mars-van Krevelen mechanism, including possible participation in reoxidation of reduced MOx.]]> Tue 22 Aug 2017 14:57:12 EST ]]> 'We shall fight, We shall win': activist knowledge in Indian documentary film (AIFRTE) Tue 22 Aug 2017 14:57:09 EST ]]> Advances in mechanical analysis of structurally and atomically modified carbon nanotubes and degenerated nanostructures: a review Tue 22 Aug 2017 14:57:07 EST ]]> Young children's use of ICT in Shanghai preschools Tue 22 Aug 2017 14:57:06 EST ]]> Between old and new: on socialism and revolutionary religion Tue 22 Aug 2017 14:57:05 EST ]]> One-step green synthesis of bimetallic Fe/Pd nanoparticles used to degrade Orange II 2+ and Pd2+, had no obvious effect on removing Orange II since less than 2.0% was removed. Kinetics study revealed that the removal rate fitted well to the pseudo-first-order reduction and pseudo-second-order adsorption model, meaning that removing Orange II via Fe/Pd NPs involved both adsorption and catalytic reduction. The remarkable stability of Fe/Pd NPs showed the potential application for removing azo dyes. Furthermore, Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR) confirmed the changes in Fe/Pd NPs before and after reaction with Orange II. High Performance Liquid Chromatography-Mass Spectrum (HPLC-MS) identified the degraded products in the removal of Orange II, and finally a removal mechanism was proposed. This one-step strategy using grape leaf aqueous extract to synthesize Fe/Pd NPs is simple, cost-effective and environmentally benign, making possible the large-scale production of Fe/Pd NPs for field remediation.]]> Tue 22 Aug 2017 14:57:04 EST ]]> Design of Raptor codes in the low SNR regime with applications in quantum key distribution Tue 22 Aug 2017 14:56:57 EST ]]> Freud, Adorno and the ban on images Tue 22 Aug 2017 14:56:53 EST ]]> Performance analysis and optimization of LT codes with unequal recovery time and intermediate feedback Tue 22 Aug 2017 14:56:51 EST ]]> Psychological therapies for children and adolescents exposed to trauma Tue 22 Aug 2017 14:56:49 EST ]]> Raptor codes in the low SNR regime Tue 22 Aug 2017 14:56:48 EST ]]> Microbial diversity and hydrocarbon degrading gene capacity of a crude oil field soil as determined by metagenomics analysis Tue 22 Aug 2017 14:56:48 EST ]]> Differential response to risperidone in schizophrenia patients by KCNH2Genotype and drug metabolizer status KCNH2. Variable patient responses and a wide range of side effects, however, limit their efficacy. Slow metabolizer status and gene variants in KCNH2 associated with increased expression of Kv11.1-3.1, an alternatively spliced isoform of Kv11.1, are correlated with improved responses to antipsychotic medications. Here, the authors test the hypothesis that these effectsmaybeinfluencedby differential drug binding to Kv11.1 channel isoforms. Method: Drug block of Kv11.1 isoforms was tested in cellular electrophysiology assays. The effects of drug metabolism and KCNH2 genotypes on clinical responses were assessed in patients enrolled in the multicenter Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE). Results: Risperidone caused greater in vitro block of the alternatively spliced Kv11.1-3.1 isoform than full-length Kv11.1-1A channels, whereas its metabolite paliperidone and other atypical antipsychotics have similar potencies for the two isoforms. In the CATIE study (N=362), patients with genotypes associated with increased Kv11.1-3.1 expression (N=52) showed a better treatment response to risperidone compared with other drugs, but this association was dependent on metabolism status. Patients with KCNH2 risk genotypes and slow metabolizer status (approximately 7% of patients) showed marked improvement in symptoms when treated with risperidone compared with patients with fast metabolizer status or without the KCNH2 risk genotypes. Conclusions: These data support the hypothesis that Kv11.1 channels play a role in the therapeutic action of antipsychotic drugs, particularly risperidone, and further highlight the promise of optimizing response with genotype-guided therapy for schizophrenia patients.]]> Tue 22 Aug 2017 14:56:46 EST ]]> Calvin, Althusser and the cunning of myth: what to do after the revolution Tue 22 Aug 2017 14:50:03 EST ]]> Interactive reflection in a photomedia participatory e-feed learning culture Tue 22 Aug 2017 14:50:01 EST ]]> A broader view of justice? Tue 22 Aug 2017 14:50:00 EST ]]> Single-stage laparoscopic cholecystectomy and intraoperative endoscopic retrograde cholangiopancreatography: is this strategy feasible in Australia? Tue 22 Aug 2017 14:49:58 EST ]]> Local vector control applied to current control Tue 22 Aug 2017 14:49:58 EST ]]> An exploration of perceptions of disaster nursing and disaster preparedness among Australian nursing undergraduates Tue 22 Aug 2017 14:49:56 EST ]]> Rapid reviews in health policy: a study of intended use in the New South Wales' Evidence Check programme Tue 22 Aug 2017 14:49:56 EST ]]> The economic politics of Biblical narrative Tue 22 Aug 2017 14:49:54 EST ]]> Althusser's religious revolution Tue 22 Aug 2017 14:49:47 EST ]]> Control of the modular multilevel converter as a photovoltaic interface under unbalanced irradiance conditions with MPPT of each PV array Tue 22 Aug 2017 14:42:46 EST ]]> Youth, health and morality: body work and health assemblages Tue 22 Aug 2017 14:35:51 EST ]]> Dissipation tests in saline environment Tue 22 Aug 2017 14:35:48 EST ]]> Some comments on the CPTu and DMT dissipation tests t50 is related to the inflexion point of the total stress-time curve. The u₂ dissipation tests are evaluated by two previously suggested, mathematically-precise methods and by the Teh-Houlsby method. Results show that the testing time can be considerably reduced by applying the mathematically-precise methods.]]> Tue 22 Aug 2017 14:35:48 EST ]]> On the determination of the undrained shear strength from vane shear testing in soft clays Tue 22 Aug 2017 14:35:46 EST ]]> HPV-associated atypical mitotic figures in squamous intraepithelial lesions of the lower female genital tract Tue 22 Aug 2017 14:35:46 EST ]]> Graph-theoretic approaches to two-sender index coding Tue 22 Aug 2017 14:28:53 EST ]]> Reported health behaviour changes after a diagnosis of gestational diabetes mellitus among ethnic minority women living in Canada Tue 22 Aug 2017 14:28:52 EST ]]> Geotechnical characterization of Ballina clay Tue 22 Aug 2017 14:28:51 EST ]]> Predictors of low diabetes risk perception in a multi-ethnic cohort of women with gestational diabetes mellitus Tue 22 Aug 2017 14:28:49 EST ]]> Session report on sampling and laboratory testing Tue 22 Aug 2017 14:28:49 EST ]]> Demographic factors and risk perceptions at work: how safe do employees feel? Tue 22 Aug 2017 14:28:47 EST ]]> Influence of risk communication on intention to prepare for flood hazards in informal settlements Tue 22 Aug 2017 14:28:46 EST ]]> Paris: The dilemmas of international climate change negotiations and the role of linked Emissions Trading Schemes in the post-2020 regime Mon 21 Aug 2017 16:59:24 EST ]]> Effect of slope height and horizontal forces on the bearing capacity of strip footings near slopes in cohesionless soil Mon 21 Aug 2017 16:59:02 EST ]]> Alcohol control policies in Indigenous communities: a qualitative study of the perceptions of their effectiveness among service providers, stakeholders and community leaders in Queensland (Australia) Mon 21 Aug 2017 16:53:51 EST ]]> EZH2 as a mediator of treatment resistance in melanoma Mon 21 Aug 2017 16:53:50 EST ]]> Association of pembrolizumab with tumor response and survival among patients with advanced melanoma Mon 21 Aug 2017 16:53:49 EST ]]> Information criterion-based channel estimation in OFDM systems with time and frequency offset Mon 21 Aug 2017 16:53:48 EST ]]> An equivalence between secure network and index coding Mon 21 Aug 2017 16:53:47 EST ]]> Identification of eight different isoforms of the glucocorticoid receptor in guinea pig placenta: relationship to preterm delivery, sex and betamethasone exposure Mon 21 Aug 2017 16:25:53 EST ]]> Salinity tolerances of two Australian freshwater turtles, Chelodina expansa and Emydura macquarii (Testudinata: Chelidae) Mon 21 Aug 2017 16:25:49 EST ]]> Targeting MicroRNA function in respiratory diseases: mini-review Mon 21 Aug 2017 16:25:49 EST ]]> Ex vivo intestinal sacs to assess mucosal permeability in models of gastrointestinal disease Mon 21 Aug 2017 16:19:21 EST ]]> TecPIV - a MATLAB-based application for PIV-analysis of experimental tectonics Mon 21 Aug 2017 16:19:20 EST ]]> Prevalence and associations of general practice nurses' involvement in consultations of general practitioner registrars: a cross-sectional analysis Mon 21 Aug 2017 16:19:19 EST ]]> The rediscovery of the mask Mon 21 Aug 2017 16:19:16 EST ]]> Biased relevance filtering in the auditory system: a test of confidence-weighted first-impressions Mon 21 Aug 2017 16:19:13 EST ]]> Cardiac function after the immediate transitional period in very preterm infants using speckle tracking analysis Mon 21 Aug 2017 16:19:11 EST ]]> Using startle reflex to compare playing and watching in a horror game Mon 21 Aug 2017 16:19:10 EST ]]> Fully roll-to-roll prepared organic solar cells in normal geometry with a sputter-coated aluminium top-electrode Mon 21 Aug 2017 16:19:01 EST ]]> Is alveolar macrophage phagocytic dysfunction in children with protracted bacterial bronchitis a forerunner to bronchiectasis? Mon 21 Aug 2017 16:19:00 EST ]]> Advances and challenges in the design and synthesis of molecularly imprinted microspheres Mon 21 Aug 2017 16:18:59 EST ]]> Prostate external beam radiotherapy combined with high-dose-rate brachytherapy: dose-volume parameters from deformably-registered plans correlate with late gastrointestinal complications Mon 21 Aug 2017 16:18:57 EST ]]> Ovarian suppression in a marsupial following single treatment with a gonadotrophin-releasing hormone agonist in microspheres Mon 21 Aug 2017 16:18:56 EST ]]> Stomach-specific activation of oncogenic KRAS and STAT3-dependent inflammation cooperatively promote gastric tumorigenesis in a preclinical model Tff1) gene and the tamoxifen-inducible Cre recombinase (CreERT2)–coding sequence. The resulting Tg(Tff1-CreERT2) mice were crossed with mice harboring conditional oncogenic mutations in Kras or Braf. The administration of tamoxifen to the resulting adult Tg(Tff1-CreERT2);KrasLSL-G12D/+ and Tg(Tff1-CreERT2);BrafLSL-V600E/+ mice resulted in gastric metaplasia, inflammation, and adenoma development, characterized by excessive STAT3 activity. To assess the contribution of STAT3 to the spontaneously developing gastric adenomas in gp130F/F mice, which carry a knockin mutation in the Il6 signal transducer (Il6st), we generated Tg(Tff1-CreERT2);Stat3fl/fl;gp130F/F mice that also harbor a conditional Stat3 knockout allele and found that tamoxifen administration conferred a significant reduction in their tumor burden. Conversely, excessive Kras activity in Tg(Tff1-CreERT2);KrasLSL-G12D/+;gp130F/F mice promoted more extensive gastric inflammation, metaplastic transformation, and tumorigenesis than observed in Tg(Tff1-CreERT2);KrasLSL-G12D/+ mice. Collectively, our findings demonstrate that advanced gastric tumorigenesis requires oncogenic KRAS or BRAF in concert with aberrant STAT3 activation in epithelial precursor cells of the glandular stomach, providing a new conditional model of gastric cancer in which to investigate candidate therapeutic targets and treatment strategies.]]> Mon 21 Aug 2017 16:18:54 EST ]]> Analytical and conceptual issues in the interpretation of doubly constrained spatial interaction models Mon 21 Aug 2017 16:18:54 EST ]]> From indole to pyrrole, furan, thiophene and pyridine: search for novel small molecule inhibitors of bacterial transcription initiation complex formation 70/σA interaction as determined by ELISA and exhibiting increased inhibition of the growth of Escherichia coli compared to Bacillus subtilis in culture. The structural features of the synthesized transcription initiation inhibitors needed for antibacterial activity were identified employing molecular modelling and structure–activity relationship (SAR) studies.]]> Mon 21 Aug 2017 16:18:52 EST ]]> Children's literacy play environments: snapshots of practitioner research for change Mon 21 Aug 2017 16:18:52 EST ]]> Relationship between collateral status, contrast transit, and contrast density in acute ischemic stroke Mon 21 Aug 2017 16:18:50 EST ]]> Practical design and validation of an LCL DC-DC converter Mon 21 Aug 2017 16:18:49 EST ]]> Disrupting demography: population collapse and rebound Mon 21 Aug 2017 16:11:58 EST ]]> A model of children's growth and adaptation to nutritional stress Mon 21 Aug 2017 16:11:58 EST ]]> Barriers to the acceptance of work colleagues infected with Hepatitis B and Hepatitis C in Japan Mon 21 Aug 2017 16:11:56 EST ]]> Growing up our way: beyond social determinants in the aetiology of growth faltering Mon 21 Aug 2017 16:11:54 EST ]]> Correlation between tea consumption and prevalence of hypertension among Singaporean Chinese residents aged ≥40 years 25 kg m -2, OR: 2.10-2.11, P<0.01), family history of hypertension (OR: 2.69-2.76, P<0.01), diabetes history (OR: 2.29-2.33, P<0.01), hyperlipidemia history (OR: 1.79-1.80, P<0.01), male (OR: 1.56-1.59, P<0.01) and coffee intake (OR: 1.44-1.46, P<0.05). In contrast, drinking green tea at least 150 ml per week was associated with lower hypertension risk (OR: 0.63, 95% confidence interval (CI): 0.43-0.91, P<0.05). Drinking combination of green tea and British tea was associated with higher reduction in the risk of hypertension (OR: 0.58, 95% CI: 0.39-0.85, P<0.05). This cross-sectional study suggests that consumption of tea, especially green tea and British tea, was associated with lowering the risk of hypertension. On the other hand, consumption of coffee could be a risk factor of hypertension. These findings may provide useful information for health promotion to reduce risk of hypertension and warrant further study to confirm and elucidate such association.]]> Mon 21 Aug 2017 16:11:51 EST ]]> Predictors of warfarin non-adherence in younger adults after valve replacement surgery in the South Pacific 1 hour (OR=5.80, p=0.039). Conclusions: While medication adherence is complex and multifactorial, the consequences of warfarin non-adherence are potentially catastrophic. These results provide an important first step towards the development of country-specific and disease-specific strategies to improve warfarin adherence.]]> Mon 21 Aug 2017 16:11:49 EST ]]> Reflections Mon 21 Aug 2017 16:11:49 EST ]]> Coolibah's story: structural violence in the twentieth century Mon 21 Aug 2017 16:11:48 EST ]]> The destruction of food resources at the colonial frontier Mon 21 Aug 2017 16:11:47 EST ]]> Strategic evacuation planning with pedestrian guidance and bus routing: a mixed integer programming model and heuristic solution Mon 21 Aug 2017 16:11:46 EST ]]> Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept Mon 21 Aug 2017 16:08:09 EST ]]> GPU acceleration of an entroy-based model to quantify epistatic interactions between SNPs Mon 21 Aug 2017 15:43:45 EST ]]> Mediation and psychological priming Mon 21 Aug 2017 12:20:47 EST ]]> Calibration of Australian atandard AS3600 concrete structures: part I statistical analysis of material properties and model error Mon 21 Aug 2017 11:59:46 EST ]]> A woman's place: constructing women within true crime narratives Famous Detective Stories, which allowed mid-twentieth century true crime writers to re-ignite debates around publishing and punishment found in the original reportage. Almost 130 years after the first of these crimes took place, this article contends offering a feminist framework to review these, and similar, cases demonstrate circulation figures and discussions around the ethics of punishment are not dependent upon the appropriation of the female body.]]> Mon 21 Aug 2017 11:36:18 EST ]]> Roles of aquaporins in setaria viridis stem development and sugar storage Mon 21 Aug 2017 11:24:48 EST ]]> MicroRNA: small RNA mediators of the brains genomic response to environmental stress Mon 21 Aug 2017 11:24:48 EST ]]> Matrix constructions of centroid sets for classification systems Mon 21 Aug 2017 11:18:02 EST ]]> Behaviour of NSM FRP masonry bond under elevated temperatures Mon 21 Aug 2017 11:17:59 EST ]]> Ex-situ remediation technologies for environmental pollutants: a critical perspective Mon 21 Aug 2017 11:17:56 EST ]]> Patterns, predictors and outcomes of asthma control and exacerbations during pregnancy: a prospective cohort study Mon 21 Aug 2017 11:17:48 EST ]]> In utero programming of allergic susceptibility Mon 21 Aug 2017 11:11:08 EST ]]> Acute heart failure admissions in New South Wales and the Australian Capital Territory: the NSW HF Snapshot Study Mon 21 Aug 2017 11:11:07 EST ]]> Paediatric pharmacokinetics and drug doses Mon 21 Aug 2017 11:11:06 EST ]]> Longitudinal analysis of associations between women's consultations with complementary and alternative medicine practitioners/use of self-prescribed complementary and alternative medicine and menopause-related symptoms, 2007-2010 Mon 21 Aug 2017 11:11:05 EST ]]> Experimental assessment of dynamic digital-to-analog converter performance for applications in precision mechatronic systems Mon 21 Aug 2017 11:11:05 EST ]]> Women's attitudes towards the use of complementary and alternative medicine products during pregnancy Mon 21 Aug 2017 11:11:01 EST ]]> What impact do essential newborn care practices have on neonatal mortality in low and lower-middle income countries? Evidence from Bangladesh Mon 21 Aug 2017 11:10:58 EST ]]> Complementary and alternative medicine use for constipation: a critical review focusing upon prevalence, type, cost, and users' profile, perception and motivations Mon 21 Aug 2017 11:10:56 EST ]]> Complementary and alternative medicine practitioner use prior to pregnancy predicts use during pregnancy Mon 21 Aug 2017 11:10:55 EST ]]> Pentexonomy: a multi-dimensional taxonomy of educational online technologies Mon 21 Aug 2017 11:10:53 EST ]]>