http://nova.newcastle.edu.au/vital/access/services/Feed ${session.getAttribute("locale")} 5 http://nova.newcastle.edu.au/vital/access/manager/Repository/uon:11700 The well-known Bounded Real Lemma plays a key role in ℒ₂-gain based control methods such as H_∞ control for both linear and nonlinear systems. Recently, conventional (linear) ℒ₂-gain concepts have been generalized to the nonlinear ℒ₂ framework to encompass a larger class of systems. A bounded real lemma has been developed corresponding to this generalized notion of nonlinear ℒ₂-gain. 2012-10-11T23:07:36.794Z ]]> http://nova.newcastle.edu.au/vital/access/manager/Repository/uon:6660 Gamma-aminobutyric acid (GABA) is the major inhibitory transmitter in the brain, and its fast effects are mediated by the GABA-A receptor. It is well known, from pharmacological manipulations, that many exogenous agents alter the efficacy of GABA-A receptors. For example, benzodiazepines increase the effect of GABA and some β-carbolines reduce the effect of GABA at these receptors. Increasing the strength of neuronal inhibition can prevent seizures, reduce anxiety and be neuroprotective. There are also endogenous mechanisms that increase efficacy. For example, more GABA-A receptors can be synthesized and inserted into synapses, but this requires up to 1 h or more. On a shorter timescale, GABAergic inhibition can be potentiated by steroids, e.g., allopregnanolone, synthesized de novo in neural tissue or derived from peripheral endocrine organs. The widespread distribution of these neuroactive steroids across the brain suggests an extensive role in short-term neural plasticity. 2010-09-10T02:50:05.067Z ]]>