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Date: 2009
Resource Type: journal article
Identifier: uon:7891
Description: Upon ejaculation, spermatozoa undergo a series of post-translational modifications in a process known as capacitation in order to prepare for fertilization. In the absence of capacitation, fertilizati... More
Reviewed: Reviewed
Date: 2009
Resource Type: journal article
Identifier: uon:8305
Description: There is an urgent need to develop safe, effective, dual-purpose contraceptive agents that combine the prevention of pregnancy with protection against sexually transmitted diseases. Here we report the... More
Reviewed: Reviewed
Date: 2008
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/42858
Description: The process of capacitation is a pre-requisite for mammalian spermatozoa allowing them to gain the ability to fertilize an oocyte. A fundamental part of this mechanism is a dramatic increase in the le... More
Reviewed: Reviewed
Date: 2008
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/39937
Description: Despite over a decade of research, only recently have the mechanisms governing transient receptor potential channel (TRPC) channel function begun to emerge, with an essential role for accessory protei... More
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Reviewed: Reviewed
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Date: 2006
Resource Type: journal article
Identifier: uon:1286
Description: Fertilization of the mammalian oocyte depends on the ability of spermatozoa to undergo a process known as capacitation as they ascend the female reproductive tract. A fundamental feature of this proce... More
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Reviewed: Reviewed
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Date: 2006
Resource Type: journal article
Identifier: uon:3007
Description: The objectives of this study were to map the ontogeny of tyrosine phosphorylation signal transduction pathways during germ cell development and to determine their association with the differentiation ... More
Reviewed: Reviewed
Date: 2005
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/24489
Description: Alkaline gel electrophoresis, pulsed field gel electrophoresis, and quantitative PCR analyses (QPCR) of the nuclear (nDNA) and mitochondrial (mtDNA) genomes were used to assess DNA integrity in the sp... More
Reviewed: Reviewed
Date: 2005
Resource Type: journal article
Identifier: uon:1619
Description: Various members of the canonical family of transient receptor potential channels (TRPCs) exhibit increased cation influx following receptor stimulation or Ca²⁺ store depletion. Tyrosine phosphorylatio... More
Reviewed: Reviewed
Date: 2005
Resource Type: journal article
Identifier: uon:1527
Description: Mammalian spermatozoa must become `capacitated' in the female reproductive tract before they gain the ability to fertilize the oocyte. The attainment of a capacitated state has been correlated with a ... More
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Date: 2005
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/24450
Description: Lucigenin-dependent chemiluminescence together with 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1) reduction can be detected following addition of NADH... More
Reviewed: Reviewed
Date: 2005
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/24511
Description: Difference in two-dimensional (2-D) gel electrophoresis (DIGE) is a novel method for analyzing up to three samples in one 2-D gel and using the information gained to study post-translational modificat... More
Reviewed: Reviewed
Date: 2004
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/29379
Description: The capacitation of mammalian spermatozoa involves the activation of a cAMP-mediated signal transduction pathway that drives tyrosine phosphorylation via mechanisms that are unique to this cell type. ... More
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Reviewed: Reviewed
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Date: 2004
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/29378
Description: Capacitation has been correlated with the activation of a cAMP–PKA-dependent signaling pathway leading to protein tyrosine phosphorylation. The ability to exhibit this response to cAMP matures during ... More
Reviewed: Reviewed
Date: 2004
Language: eng
Resource Type: conference paper
Identifier: http://hdl.handle.net/1959.13/32684
Description: Prior to fertilisation, mammalian spermatozoa undergo a series of molecular and biochemical events that render them capable of interacting with the oocyte. This process, termed capacitation, has been ... More
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