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Date: 2016
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1342711
Description: The hypothesis that phosphorylation of progesterone receptor (PR) isoforms, PR-A and PR-B, in myometrial cells affects progesterone action in the context of human parturition was tested. Immunodetecti... More
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1060660
Description: Allopregnanolone is a neurosteroid synthesized from progesterone in brain. It increases inhibition through modulation of the gamma-aminobutyric acid type A (GABA-A) receptor. Both agents are putative ... More
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Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1307261
Description: Problem: Susceptibility to Chlamydia trachomatis infection is increased by oral contraceptives and modulated by sex hormones. We therefore sought to determine the effects of female sex hormones... More
Reviewed: Reviewed
Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1059071
Description: Background: Preterm birth is a major cause of neurodevelopmental disorders. Allopregnanolone, a key metabolite of progesterone, has neuroprotective and developmental effects in the brain. The objectiv... More
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Date: 2012
Language: eng
Resource Type: thesis
Identifier: http://hdl.handle.net/1959.13/936340
Description: Research Doctorate - Doctor of Philosphy (PhD)
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Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1054202
Description: Estrogens are key mediators of increased uterine contractility at labor. We sought to determine whether membrane-associated estrogen receptors, such as the recently described seven-transmembrane recep... More
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Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1059769
Description: Most of us owe our existence to the calming influence of progesterone on our mother's uterine muscle (the myometrium). By the third trimester of pregnancy, the myometrium is akin to a sleeping giant. ... More
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Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1053865
Description: Chlamydia trachomatis is a major cause of sexually transmitted disease in humans. Previous studies in both humans and animal models of chlamydial genital tract infection have suggested that the hormon... More
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Date: 2011
Language: eng
Resource Type: book chapter
Identifier: http://hdl.handle.net/1959.13/1052042
Description: The physiology of parturition in mammals is highly diverse and almost species specific. A range of examples is presented from the marsupial Tammar wallaby (Macropus eugenii) to the primate Homo sapien... More
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1056014
Description: Preterm birth is a significant global health problem with serious short and long term consequences. This paper reviews the research literature to answer the question how effective are the medical inte... More
Reviewed: Reviewed
Date: 2010
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/922472
Description: Background: Sufficient information from in vitro and in vivo studies has become available to permit computer modeling of the processes that occur in the myometrium during labor. This development allow... More
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Date: 2010
Language: eng
Resource Type: book chapter
Identifier: http://hdl.handle.net/1959.13/929136
Description: Placental corticotrophin releasing hormone (CRH) determines the length of pregnancy. CRH drives fetal adrenal production of dehydroepiandrosterone sulfate (DHEAS). DHEAS is converted into estriol in t... More
Date: 2009
Resource Type: journal article
Identifier: uon:7579
Description: Context: Clinical prediction of preterm delivery is largely ineffective, and the mechanism mediating progesterone (P) withdrawal and estrogen activation at the onset of human labor is unclear. Objecti... More
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Date: 2008
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/41466
Description: Complications during pregnancy and birth asphyxia lead to brain injury, with devastating consequences for the neonate. In this paper we present evidence that the steroid environment during pregnancy a... More
Reviewed: Reviewed
Date: 2006
Resource Type: journal article
Identifier: uon:986
Description: Neurosteroids such as allopregnanolone are potent agonists at the GABAA receptor and suppress the fetal CNS activity. These steroids are synthesized in the fetal brain either from cholester... More
Reviewed: Reviewed