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Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1324637
Description: Cognitive deficits are a core feature of schizophrenia and contribute significantly to functional disability. We investigated the molecular pathways associated with schizophrenia (SZ; n=47) cases repr... More
Reviewed: Reviewed
Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1045122
Description: Abstract: Hereditary non-polyposis colorectal cancer (HNPCC) is the commonest form of inherited colorectal cancer (CRC) predisposition and by definition describes families which conform to the Amsterd... More
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Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1313256
Description: Background: Dietary supplementation with omega-3 fatty acids has been associated with reduced incidence in thrombotic events. In addition, administration of n-3 polyunsaturated fatty acids (PUFAs) has... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1063607
Description: Over the last decades, the involvement of free radicals and oxidative stress in the molecular mechanisms related to ageing, cancer, atherosclerosis, neurodegenerative disorders, diabetes, and inflamma... More
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Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1056094
Description: Whether mouse models of chronic asthma can be used to investigate the relationship between airway inflammation/remodeling and airway hyper-responsiveness (AHR) is a vexed question. It raises issues ab... More
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Creators: van der Luijt, B. | Devilee, P. | EMBRACE, | Easton, D. F. | Peock, S. | Frost, D. | Platte, R. | Ellis, S. D. | Fineberg, E. | Evans, D. G. | Lalloo, F. | Eeles, R. | Jacobs, C. | Adlard, J. | Davidson, R. | Eccles, D. | Cole, T. | Cook, J. | Godwin, A. | Bove, B. | GEMO Study Collaborators, | Stoppa-Lyonnet, D. | Caux-Moncoutier, V. | Coupier, I. | Peyrat, J.-P. | Vennin, P. | Muller, D. | Fricker, J. P. | Venat-Bouvet, L. | Johannsson, O. Th. | Isaacs, C. | Schmutzler, R. | Wappenschmidt, B. | Meindl, A. | Arnold, N. | Varon-Mateeva, R. | Niederacher, D. | Sutter, C. | Deissler, H. | Preisler-Adams, S. | Simard, J. | Soucy, P. | Durocher, F. | Chenevix-Trench, G. | Beesley, J. | Chen, X. | ConFab, K. | Rebbeck, T. | Couch, F. | Wang, X. | Lindor, N. | Fredericksen, Z. | Pankratz, V. S. | Peterlongo, P. | Bonanni, B. | Fortuzzi, S. | Peissel, B. | Szabo, C. | Mai, P. L. | Loud, J. T. | Lubinski, J. | Jakubowska, A. | Rozkrut, D. | Antoniou, A. | Hamann, U. | Scott, R. J. | McGuffog, L. | Healy, S. | Sinilnikova, O. M. | Rennert, G. | Lejbkowicz, F. | Flugelman, A. | Andrulis, I. L. | Glendon, G. | Ozcelik, H. | Thomassen, M. | Paligo, M. | Aretini, P. | Kantala, J. | Aroer, B. | Von Wachenfeldt, A. | Liljegren, A. | Loman, N. | Herbst, K. | Kristoffersson, U. | Rosenquist, R. | Karlsson, P. | Stenmark-Askmalm, M. | Melin, B. | Nathanson, K. L. | Domchek, S. M. | Byrski, T. | Huzarski, T. | Gronwald, J. | Menkiszak, J. | Cybulski, C. | Serrano, P. | Osorio, A. | Cajal, T. R. | Tsitlaidou, M. | Benitez, J. | Gilbert, M. | Rookus, M. | Aalfs, C. M. | Kluijt, I. | Boessenkool-Pape, J. L. | Meijers-Heijboer, H. E. J. | Oosterwijk, J. C. | Van Asperen, C. J. | Blok, M. J. | Nelen, M. R. | Van Den Ouweland, A. M. W. | Seynaeve, C.
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1324807
Description: Background: The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are proh... More
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Reviewed: Reviewed
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Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1063655
Description: Aneuploidy is a leading cause of early embryo loss, miscarriage and birth defects in humans. It is predominantly brought about by the mis-segregation of homologous chromosomes (bivalents) in the first... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: book chapter
Identifier: http://hdl.handle.net/1959.13/1310820
Description: The treatment of hyperlipidemia, particularly reducing LDL-cholesterol and triglyceride concentration, is established as an efficacious means of reducing both morbidity and mortality from CVD. Dietary... More
Creators: Bogduk, Nikolai
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1325440
Description: Degenerative changes are the manifestations of metabolic disturbances in the matrix of intervertebral disks and zygapophysial joints. Genetic factors and physical loading contribute, but the strongest... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1296365
Description: Obesity is associated with elevated levels of inflammation and metabolic abnormalities which are linked to CVD. The aim of the present study was to investigate whether long-chain n-3 PUFA (LCn-3PUFA),... More
Reviewed: Reviewed
Date: 2012
Keyword: cyclin B1 | securin | MPF | meiosis | bovine | oocytes
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1324737
Description: During mammalian oocyte maturation, two consecutive meiotic divisions are required to form a haploid gamete. For each meiotic division, oocytes must transfer from metaphase to anaphase, but maturation... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1059068
Description: Clinically, treatment options where fetal distress is anticipated or identified are limited. Allopregnanolone is an endogenous steroid, that positively modulates the GABAA receptor, and tha... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1324743
Description: The advent of real-time macromolecular sequencing is opening the way for new levels of understanding of dynamic biological states and new approaches to point-of-care diagnosis and drug discovery. This... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1056105
Description: Asthma is recognized as a heterogeneous disorder, although in most patients, the clinical manifestations are effectively managed with established combination therapies. However, 5–10% of asthmatics ha... More
Reviewed: Reviewed