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Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1322963
Description: Multiple sclerosis (MS) is a chronic relapsing-remitting inflammatory disease of the central nervous system characterized by oligodendrocyte damage, demyelination and neuronal death. Genetic associati... More
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Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1311581
Description: Genome-wide association studies (GWAS) have identified around 60 common variants associated with multiple sclerosis (MS), but these loci only explain a fraction of the heritability of MS. Some missing... More
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Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1295197
Description: Multiple sclerosis (MS) is a common chronic inflammatory disease of the central nervous system. Susceptibility to the disease is affected by both environmental and genetic factors. Genetic factors inc... More
Reviewed: Reviewed
Creators: Lill, Christina M. | Liu, Tian | Blaschke, Paul | Winkelmann, Alexander | Gerdes, Lisa-Ann | Luessi, Felix | Fernadez, Oscar | Izquierdo, Guillermo | Antiguedad, Alfredo | Hoffjan, Sabine | Cournu-Rebeix, Isabelle | Gromoller, Silvana | Schjeide, Brit-Maren M. | Faber, Hans | Liebsch, Maria | Meissner, Esther | Chanvillard, Coralie | Touze, Emmauel | Pico, Fernando | Corcia, Philippe | Bahlo, Melanie | Booth, David R. | Broadley, Simon | Roehr, Johannes T. | Brown, Matthew A. | Browning, Brian L. | Browning, Sharon R. | Butzkueven, Helmut | Carroll, William M. | Cox, Mathew B. | Chapman, Caron | Clarke, Glynnis | Danoy, Patrick | Drysdale, Karen | Akkad, Denis A. | Field, Judith | Foote, Simon J. | Greer, Judith M. | Griffiths, Lyn R. | Hadler, Johanna | Jensen, Cathy J. | Johnson, Laura J. | Kermode, Allan G. | Heard, Robert N. | Kilpatrick, Trevor J. | Damotte, Vincent | Lechner-Scott, Jeanette | Marriott, Mark | Mason, Deborah | Moscato, Pablo | Pender, Michael P. | Perreau, Victoria M. | Rubio, Justin P. | Scott, Rodney J. | Slee, Mark | Stankovich, Jim | Alcina, Antonio | Stewart, Graeme J. | Tajouri, Lofti | Taylor, Bruce V. | Wiley, James | Wilkins, Ella J. | Dörner, Thomas | Steinhagen-Thiessen, Elisabeth | Baeckman, Lars | Heekeren, Hauke R. | Li, Shu-Chen | Ortiz, Miguel A. | Lindenberger, Ulman | Chan, Andrew | Hartung, Hans-Peter | Aktas, Orhan | Lohse, Peter | Kümpfel, Tania | Kubisch, Christian | Epplen, Joerg T. | Zettl, Uwe K. | Fontaine, Bertrand | Arroyo, Rafa | Vandenbroeck, Koen | Matesanz, Fuencisla | Urcelay, Elena | Bertram, Lars | Zipp, Frauke | Lopez de Lapuente, Aitzkoa
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1326050
Description: Background: Single nucleotide polymorphisms (SNPs) rs429358 (ε4) and rs7412 (ε2), both invoking changes in the amino-acid sequence of the apolipoprotein E (APOE) gene, have previously been tested for ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1326960
Description: Background: Vulvar cancer is a relatively rare malignancy, which occurs most often in postmenopausal women. We have previously identified a geographic cluster of vulvar cancer in young Indigenous wome... More
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Date: 2011
Keyword: SNP | Illuminus | genes
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1039569
Description: Illumina's Infinium SNP BeadChips are extensively used in both small and large-scale genetic studies. A fundamental step in any analysis is the processing of raw allele A and allele B intensities from... More
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Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/939604
Description: Objective: To perform a 1-stage meta-analysis of genome-wide association studies (GWAS) of multiple sclerosis (MS) susceptibility and to explore functional consequences of new susceptibility loci. Met... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1039565
Description: Multiple sclerosis (MS) is a debilitating, chronic demyelinating disease of the central nervous system affecting over 2 million people worldwide. The TAM family of receptor tyrosine kinases (T̲YRO3, A... More
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Date: 2010
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1039576
Description: We conducted an association study across the human leukocyte antigen (HLA) complex to identify loci associated with multiple sclerosis (MS). Comparing 1927 SNPs in 1618 MS cases and 3413 controls of E... More
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Date: 2010
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1039757
Description: Recent association studies in multiple sclerosis (MS) have identified and replicated several single nucleotide polymorphism (SNP) susceptibility loci including CLEC16A, IL2RA, IL7R, RPL5, CD58, CD40 a... More
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Date: 2010
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/922584
Description: Multiple sclerosis (MS) is an autoimmune disease with a genetic component, caused at least in part by aberrant lymphocyte activity. The whole blood mRNA transcriptome was measured for 99 untreated MS ... More
Reviewed: Reviewed
Date: 2009
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/807808
Description: To identify multiple sclerosis (MS) susceptibility loci, we conducted a genome-wide association study (GWAS) in 1,618 cases and used shared data for 3,413 controls. We performed replication in an inde... More
Reviewed: Reviewed
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